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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/9113

Appears in Collections:Computing Science and Mathematics Journal Articles
Peer Review Status: Refereed
Title: Bovine tuberculosis (Mycobacterium bovis) in British farmland wildlife: the importance to agriculture
Author(s): Mathews, Fiona
Macdonald, David
Taylor, G Michael
Gelling, Merryl
Norman, Rachel
Honess, Paul
Foster, Rebecca
Gower, Charlotte M
Varley, Susan
Harris, Audrey
Palmer, Simonette
Hewinson, Glyn
Webster, Joanne P
Contact Email: ran@maths.stir.ac.uk
Keywords: bovine tuberculosis
Mycobacterium bovis
epidemiology
voles
PCR
mycobacterium microti
Issue Date: 7-Feb-2006
Publisher: The Royal Society
Citation: Mathews F, Macdonald D, Taylor GM, Gelling M, Norman R, Honess P, Foster R, Gower CM, Varley S, Harris A, Palmer S, Hewinson G & Webster JP (2006) Bovine tuberculosis (Mycobacterium bovis) in British farmland wildlife: the importance to agriculture, Proceedings of the Royal Society B: Biological Sciences, 273 (1584), pp. 357-365.
Abstract: Bovine tuberculosis (bTB) is an important disease of cattle and an emerging infectious disease of humans. Cow- and badger-based control strategies have failed to eradicate bTB from the British cattle herd, and the incidence is rising by about 18% per year. The annual cost to taxpayers in Britain is currently £74 million. Research has focused on the badger as a potential bTB reservoir, with little attention being paid to other mammals common on farmland. We have conducted a systematic survey of wild mammals (n=4393 individuals) present on dairy farms to explore the role of species other than badgers in the epidemiology of bTB. Cultures were prepared from 10 397 samples (primarily faeces, urine and tracheal aspirates). One of the 1307 bank voles (Clethrionomys glareolus) live-sampled, and three of the 43 badgers (Meles meles), yielded positive isolates of Mycobacterium bovis. This is the first time the bacterium has been isolated from the bank vole. The strain type was the same as that found in cattle and badgers on the same farm. However, our work indicates that the mean prevalence of infectious individuals among common farmland wildlife is extremely low (the upper 95% confidence interval is ≤2.0 for all of the abundant species). Mathematical models illustrate that it is highly unlikely the disease could be maintained at such low levels. Our results suggest that these animals are relatively unimportant as reservoirs of bTB, having insufficient withinspecies (or within-group) transmission to sustain the infection, though occasional spill-overs from cattle or badgers may occ
Type: Journal Article
URI: http://hdl.handle.net/1893/9113
URL: http://rspb.royalsocietypublishing.org/content/273/1584/357
DOI Link: http://dx.doi.org/10.1098/rspb.2005.3298
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Oxford
University of Oxford
Imperial College London
University of Oxford
Mathematics - CSM Dept
University of Oxford
University of Oxford
University of Oxford
University of Oxford
Department for Environment Food & Rural Affairs (DEFRA)
Veterinary Laboratories Agency
Veterinary Laboratories Agency
University of Oxford

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