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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Degradation of specific polyunsaturated fatty acids in red blood cells stored at -20 degrees Celsius proceeds faster in patients with schizophrenia when compared with healthy controls
Author(s): Fox, Helen
Ross, Brian M
Tocher, Douglas R
Horrobin, David
Glen, Iain
St, Clair David
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Issue Date: Nov-2003
Publisher: Elsevier
Citation: Fox H, Ross BM, Tocher DR, Horrobin D, Glen I & St Clair D (2003) Degradation of specific polyunsaturated fatty acids in red blood cells stored at -20 degrees Celsius proceeds faster in patients with schizophrenia when compared with healthy controls, Prostaglandins, Leukotrienes and Essential Fatty Acids, 69 (5), pp. 291-297.
Abstract: Deficits in red blood cell (RBC) polyunsaturated fatty acids (PUFAs) have been extensively reported in schizophrenia although reports are inconsistent. A possible explanation for this inconsistency is varying storage conditions of blood samples prior to analysis, especially freezer storage temperature. We conducted a prospective investigation of fatty acid degradation rates in RBCs from healthy control subjects when samples from each individual were stored at both −20°C or −70°C. Differences were detected between storage conditions. A second prospective study was conducted to investigate the effect of differential storage conditions on RBC membrane fatty acids from schizophrenic patients. We found that storage at −20°C was associated with reduced levels of PUFAs. Comparison of decay rates suggest that schizophrenics decay approximately twice as rapidly as controls. Furthermore, this phenomenon appears to be specific for the longer chain PUFAs suggesting that an enzymatic process may be responsible, e.g. elevated phospholipase A2 activity, as opposed to simple chemical o
Type: Journal Article
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Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Royal Cornhill Hospital
UHI Millennium Institute
Laxdale Ltd
UHI Millennium Institute
Royal Cornhill Hospital

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