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dc.contributor.authorFox, Helenen_UK
dc.contributor.authorRoss, Brian Men_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorHorrobin, Daviden_UK
dc.contributor.authorGlen, Iainen_UK
dc.contributor.authorSt Clair, Daviden_UK
dc.description.abstractDeficits in red blood cell (RBC) polyunsaturated fatty acids (PUFAs) have been extensively reported in schizophrenia although reports are inconsistent. A possible explanation for this inconsistency is varying storage conditions of blood samples prior to analysis, especially freezer storage temperature. We conducted a prospective investigation of fatty acid degradation rates in RBCs from healthy control subjects when samples from each individual were stored at both −20°C or −70°C. Differences were detected between storage conditions. A second prospective study was conducted to investigate the effect of differential storage conditions on RBC membrane fatty acids from schizophrenic patients. We found that storage at −20°C was associated with reduced levels of PUFAs. Comparison of decay rates suggest that schizophrenics decay approximately twice as rapidly as controls. Furthermore, this phenomenon appears to be specific for the longer chain PUFAs suggesting that an enzymatic process may be responsible, e.g. elevated phospholipase A2 activity, as opposed to simple chemical oxidation.en_UK
dc.relationFox H, Ross BM, Tocher DR, Horrobin D, Glen I & St Clair D (2003) Degradation of specific polyunsaturated fatty acids in red blood cells stored at -20 degrees Celsius proceeds faster in patients with schizophrenia when compared with healthy controls. Prostaglandins, Leukotrienes and Essential Fatty Acids, 69 (5), pp. 291-297.
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dc.titleDegradation of specific polyunsaturated fatty acids in red blood cells stored at -20 degrees Celsius proceeds faster in patients with schizophrenia when compared with healthy controlsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[tocher_prostaglandins69_2003.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleProstaglandins, Leukotrienes and Essential Fatty Acidsen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationRoyal Cornhill Hospitalen_UK
dc.contributor.affiliationUHI Millennium Instituteen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationLaxdale Ltden_UK
dc.contributor.affiliationUHI Millennium Instituteen_UK
dc.contributor.affiliationRoyal Cornhill Hospitalen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorFox, Helen|en_UK
local.rioxx.authorRoss, Brian M|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorHorrobin, David|en_UK
local.rioxx.authorGlen, Iain|en_UK
local.rioxx.authorSt Clair, David|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Aquaculture Journal Articles

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