Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/33453
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dc.contributor.authorMikolic, Anaen_UK
dc.contributor.authorOude Groeniger, Joosten_UK
dc.contributor.authorZeldovich, Marinaen_UK
dc.contributor.authorWilson, Lindsayen_UK
dc.contributor.authorRoeters van Lennep, Jeanine Een_UK
dc.contributor.authorvan Klaveren, Daviden_UK
dc.contributor.authorPolinder, Suzanneen_UK
dc.date.accessioned2021-10-14T00:03:11Z-
dc.date.available2021-10-14T00:03:11Z-
dc.date.issued2021-10-07en_UK
dc.identifier.urihttp://hdl.handle.net/1893/33453-
dc.description.abstractMen and women differ in outcomes following mild traumatic brain injury (TBI). In the CENTER-TBI study, we previously found that women had worse 6-month functional outcome (Glasgow Outcome Score Extended (GOSE)), health-related quality of life (HRQoL), and mental health following mild TBI. The aim of this study was to investigate whether those differences were mediated by psychiatric history, gender- related sociodemographic variables, or by care pathways. We analyzed sex/gender differences in 6-month GOSE, generic and TBI-specific HRQoL, post-concussion and mental health symptoms using three sets of mediators: psychiatric history, sociodemographic variables (living alone, living with children, education and employment status/job category), and care-pathways (referral to study hospital and discharge destination after Emergency Room); while controlling for a substantial number of potential confounders (pre-injury health, and injury-related characteristics). We included 1842 men and 1022 women (16+) with a Glasgow Coma Score 13-15, amongst whom 83% had GOSE available and about 60% other 6-month outcomes. We used natural effects models to decompose the total effect of sex/gender on the outcomes into indirect effects that passed through the specified mediators, and the remaining direct effects. In our study population, women had worse outcomes and these were only partly explained by psychiatric history, and not considerably explained by sociodemographic variables nor by care pathways. Other factors than differences in specified variables seem to underlie observed differences between men and women in outcomes after mild TBI. Future studies should explore more aspects of gender roles and identity, and biological factors underpinning sex and gender differences in TBI outcomes.en_UK
dc.language.isoenen_UK
dc.publisherMary Ann Liebert Incen_UK
dc.relationMikolic A, Oude Groeniger J, Zeldovich M, Wilson L, Roeters van Lennep JE, van Klaveren D & Polinder S (2021) Explaining outcome differences between men and women following mild traumatic brain injury. Journal of Neurotrauma. https://doi.org/10.1089/neu.2021.0116en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/neu.2021.0116en_UK
dc.subjectsex differencesen_UK
dc.subjecttraumatic brain injuryen_UK
dc.subjectmediationen_UK
dc.subjectoutcomesen_UK
dc.subjectsociodemographic factorsen_UK
dc.subjectcare pathwaysen_UK
dc.titleExplaining outcome differences between men and women following mild traumatic brain injuryen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2022-10-08en_UK
dc.rights.embargoreason[Mikolic-etal-2021-JNT.pdf] Publisher requires embargo of 12 months after publication.en_UK
dc.identifier.doi10.1089/neu.2021.0116en_UK
dc.identifier.pmid34617454en_UK
dc.citation.jtitleJournal of Neurotraumaen_UK
dc.citation.issn1557-9042en_UK
dc.citation.issn0897-7151en_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderEuropean Commission (Horizon 2020)en_UK
dc.author.emaill.wilson@stir.ac.uken_UK
dc.citation.date07/10/2021en_UK
dc.description.notesOutput Status: Forthcoming/Available Onlineen_UK
dc.contributor.affiliationErasmus MC Rotterdamen_UK
dc.contributor.affiliationErasmus MC Rotterdamen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationErasmus MC Rotterdamen_UK
dc.contributor.affiliationErasmus University, Rotterdamen_UK
dc.contributor.affiliationErasmus MC Rotterdamen_UK
dc.identifier.wtid1763494en_UK
dc.contributor.orcid0000-0003-4113-2328en_UK
dc.date.accepted2021-10-07en_UK
dcterms.dateAccepted2021-10-07en_UK
dc.date.filedepositdate2021-10-13en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorMikolic, Ana|en_UK
local.rioxx.authorOude Groeniger, Joost|en_UK
local.rioxx.authorZeldovich, Marina|en_UK
local.rioxx.authorWilson, Lindsay|0000-0003-4113-2328en_UK
local.rioxx.authorRoeters van Lennep, Jeanine E|en_UK
local.rioxx.authorvan Klaveren, David|en_UK
local.rioxx.authorPolinder, Suzanne|en_UK
local.rioxx.projectProject ID unknown|European Commission (Horizon 2020)|en_UK
local.rioxx.freetoreaddate2022-10-08en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2022-10-07en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2022-10-08|en_UK
local.rioxx.filenameMikolic-etal-2021-JNT.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1557-9042en_UK
Appears in Collections:Psychology Journal Articles

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