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Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Structure of Chimpanzee Gut Microbiomes across Tropical Africa
Author(s): Bueno de Mesquita, Clifton P
Nichols, Lauren M
Gebert, Matthew J
Vanderburgh, Caihong
Bocksberger, Gaëlle
Lester, Jack D
Kalan, Ammie K
Dieguez, Paula
McCarthy, Maureen S
Agbor, Anthony
Álvarez Varona, Paula
Ayimisin, Ayuk Emmanuel
Bessone, Mattia
Chancellor, Rebecca
Jeffery, Kathryn J
Keywords: prokaryotes
host genetics
Issue Date: Jun-2021
Date Deposited: 12-Jul-2021
Citation: Bueno de Mesquita CP, Nichols LM, Gebert MJ, Vanderburgh C, Bocksberger G, Lester JD, Kalan AK, Dieguez P, McCarthy MS, Agbor A, Álvarez Varona P, Ayimisin AE, Bessone M, Chancellor R & Jeffery KJ (2021) Structure of Chimpanzee Gut Microbiomes across Tropical Africa. mSystems, 6 (3), Art. No.: e01269-20.
Abstract: Understanding variation in host-associated microbial communities is important given the relevance of microbiomes to host physiology and health. Using 560 fecal samples collected from wild chimpanzees (Pan troglodytes) across their range, we assessed how geography, genetics, climate, vegetation, and diet relate to gut microbial community structure (prokaryotes, eukaryotic parasites) at multiple spatial scales. We observed a high degree of regional specificity in the microbiome composition, which was associated with host genetics, available plant foods, and potentially with cultural differences in tool use, which affect diet. Genetic differences drove community composition at large scales, while vegetation and potentially tool use drove within-region differences, likely due to their influence on diet. Unlike industrialized human populations in the United States, where regional differences in the gut microbiome are undetectable, chimpanzee gut microbiomes are far more variable across space, suggesting that technological developments have decoupled humans from their local environments, obscuring regional differences that could have been important during human evolution.
DOI Link: 10.1128/msystems.01269-20
Rights: © 2021 Bueno de Mesquita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (
Notes: Additional co-authors: Heather Cohen, Charlotte Coupland, Tobias Deschner, Villard Ebot Egbe, Annemarie Goedmakers, Anne-Céline Granjon, Cyril C. Grueter, Josephine Head, R. Adriana Hernandez-Aguilar, Sorrel Jones, Parag Kadam, Michael Kaiser, Juan Lapuente, Bradley Larson, Sergio Marrocoli, David Morgan, Badru Mugerwa, Felix Mulindahabi, Emily Neil, Protais Niyigaba, Liliana Pacheco, Alex K. Piel, Martha M. Robbins, Aaron Rundus, Crickette M. Sanz, Lilah Sciaky, Douglas Sheil, Volker Sommer, Fiona A. Stewart, Els Ton, Joost van Schijndel, Virginie Vergnes, Erin G. Wessling, Roman M. Wittig, Yisa Ginath Yuh, Kyle Yurkiw, Klaus Zuberbühler, Jan F. Gogarten, Anna Heintz-Buschart, Alexandra N. Muellner-Riehl, Christophe Boesch, Hjalmar S. Kühl, Noah Fierer, Mimi Arandjelovic, Robert R. Dunn
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