Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/32154
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System
Author(s): Jin, Xingkun
Morro, Bernat
Tørresen, Ole K
Moiche, Visila
Solbakken, Monica H
Jakobsen, Kjetill S
Jentoft, Sissel
MacKenzie, Simon
Keywords: cod
immune response
nucleotide-binding oligomerization-like receptor (NLR)
macrophage
Toll-like receptor (TLR)
Issue Date: 2020
Citation: Jin X, Morro B, Tørresen OK, Moiche V, Solbakken MH, Jakobsen KS, Jentoft S & MacKenzie S (2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System. Frontiers in Immunology, 11, Art. No.: 609456. https://doi.org/10.3389/fimmu.2020.609456
Abstract: The absence of MHC class II antigen presentation and multiple pathogen recognition receptors in the Atlantic cod has not impaired its immune response however how underlying mechanisms have adapted remains largely unknown. In this study, ex vivo cod macrophages were challenged with various bacterial and viral microbe-associated molecular patterns (MAMP) to identify major response pathways. Cytosolic MAMP-PRR pathways based upon the NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs) were identified as the critical response pathways. Our analyses suggest that internalization of exogenous ligands through scavenger receptors drives both pathways activating transcription factors like NF-kB (Nuclear factor-kappa B) and interferon regulatory factors (IRFs). Further, ligand-dependent differential expression of a unique TLR25 isoform and multiple NLR paralogues suggests (sub)neofunctionalization toward specific immune defensive strategies. Our results further demonstrate that the unique immune system of the Atlantic cod provides an unprecedented opportunity to explore the evolutionary history of PRR-based signaling in vertebrate immunity.
DOI Link: 10.3389/fimmu.2020.609456
Rights: © 2020 Jin, Morro, Tørresen, Moiche, Solbakken, Jakobsen, Jentoft and MacKenzie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY - https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Licence URL(s): http://creativecommons.org/licenses/by/4.0/

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