Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/32154
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dc.contributor.authorJin, Xingkunen_UK
dc.contributor.authorMorro, Bernaten_UK
dc.contributor.authorTørresen, Ole Ken_UK
dc.contributor.authorMoiche, Visilaen_UK
dc.contributor.authorSolbakken, Monica Hen_UK
dc.contributor.authorJakobsen, Kjetill Sen_UK
dc.contributor.authorJentoft, Sisselen_UK
dc.contributor.authorMacKenzie, Simonen_UK
dc.date.accessioned2021-01-13T01:13:33Z-
dc.date.available2021-01-13T01:13:33Z-
dc.date.issued2020en_UK
dc.identifier.other609456en_UK
dc.identifier.urihttp://hdl.handle.net/1893/32154-
dc.description.abstractThe absence of MHC class II antigen presentation and multiple pathogen recognition receptors in the Atlantic cod has not impaired its immune response however how underlying mechanisms have adapted remains largely unknown. In this study, ex vivo cod macrophages were challenged with various bacterial and viral microbe-associated molecular patterns (MAMP) to identify major response pathways. Cytosolic MAMP-PRR pathways based upon the NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs) were identified as the critical response pathways. Our analyses suggest that internalization of exogenous ligands through scavenger receptors drives both pathways activating transcription factors like NF-kB (Nuclear factor-kappa B) and interferon regulatory factors (IRFs). Further, ligand-dependent differential expression of a unique TLR25 isoform and multiple NLR paralogues suggests (sub)neofunctionalization toward specific immune defensive strategies. Our results further demonstrate that the unique immune system of the Atlantic cod provides an unprecedented opportunity to explore the evolutionary history of PRR-based signaling in vertebrate immunity.en_UK
dc.language.isoenen_UK
dc.publisherFrontiers Media SAen_UK
dc.relationJin X, Morro B, Tørresen OK, Moiche V, Solbakken MH, Jakobsen KS, Jentoft S & MacKenzie S (2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System. Frontiers in Immunology, 11, Art. No.: 609456. https://doi.org/10.3389/fimmu.2020.609456en_UK
dc.rights© 2020 Jin, Morro, Tørresen, Moiche, Solbakken, Jakobsen, Jentoft and MacKenzie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY - https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectcoden_UK
dc.subjectimmune responseen_UK
dc.subjectnucleotide-binding oligomerization-like receptor (NLR)en_UK
dc.subjectmacrophageen_UK
dc.subjectToll-like receptor (TLR)en_UK
dc.titleInnovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune Systemen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.3389/fimmu.2020.609456en_UK
dc.identifier.pmid33362798en_UK
dc.citation.jtitleFrontiers in Immunologyen_UK
dc.citation.issn1664-3224en_UK
dc.citation.volume11en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderThe Research Council of Norwayen_UK
dc.citation.date11/12/2020en_UK
dc.contributor.affiliationUniversity of Osloen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Osloen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Osloen_UK
dc.contributor.affiliationUniversity of Osloen_UK
dc.contributor.affiliationUniversity of Osloen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000601595000001en_UK
dc.identifier.scopusid2-s2.0-85098226390en_UK
dc.identifier.wtid1694479en_UK
dc.contributor.orcid0000-0003-1845-6826en_UK
dc.date.accepted2020-11-09en_UK
dc.date.filedepositdate2021-01-11en_UK
Appears in Collections:Aquaculture Journal Articles

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