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http://hdl.handle.net/1893/27956| Appears in Collections: | Biological and Environmental Sciences Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Biomimetic oyster shell–replicated topography alters the behaviour of human skeletal stem cells |
| Author(s): | Waddell, Shona J de Andrés, María C Tsimbouri, Penelope M Alakpa, Enateri V Cusack, Maggie Dalby, Matthew J Oreffo, Richard O C |
| Keywords: | Nacre topography skeletal stem cell osteogenic differentiation bone regeneration |
| Issue Date: | 31-Dec-2018 |
| Date Deposited: | 11-Oct-2018 |
| Citation: | Waddell SJ, de Andrés MC, Tsimbouri PM, Alakpa EV, Cusack M, Dalby MJ & Oreffo ROC (2018) Biomimetic oyster shell–replicated topography alters the behaviour of human skeletal stem cells. Journal of Tissue Engineering, 9. https://doi.org/10.1177/2041731418794007 |
| Abstract: | The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell therapies to the clinic. The nacre surface from Pinctada maxima shells is known to enhance bone formation. However, to date, there is a paucity of information on the role of the topography of P. maxima surfaces, nacre and prism. To investigate this, nacre and prism topographical features were replicated onto polycaprolactone and skeletal stem cell behaviour on the surfaces studied. Skeletal stem cells on nacre surfaces exhibited an increase in cell area, increase in expression of osteogenic markers ALP (p |
| DOI Link: | 10.1177/2041731418794007 |
| Rights: | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Licence URL(s): | http://creativecommons.org/licenses/by-nc/4.0/ |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2041731418794007.pdf | Fulltext - Published Version | 1.34 MB | Adobe PDF | View/Open |
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