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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27956
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dc.contributor.authorWaddell, Shona Jen_UK
dc.contributor.authorde Andrés, María Cen_UK
dc.contributor.authorTsimbouri, Penelope Men_UK
dc.contributor.authorAlakpa, Enateri Ven_UK
dc.contributor.authorCusack, Maggieen_UK
dc.contributor.authorDalby, Matthew Jen_UK
dc.contributor.authorOreffo, Richard O Cen_UK
dc.date.accessioned2018-10-12T00:01:58Z-
dc.date.available2018-10-12T00:01:58Z-
dc.date.issued2018-12-31en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27956-
dc.description.abstractThe regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell therapies to the clinic. The nacre surface from Pinctada maxima shells is known to enhance bone formation. However, to date, there is a paucity of information on the role of the topography of P. maxima surfaces, nacre and prism. To investigate this, nacre and prism topographical features were replicated onto polycaprolactone and skeletal stem cell behaviour on the surfaces studied. Skeletal stem cells on nacre surfaces exhibited an increase in cell area, increase in expression of osteogenic markers ALP (p en_UK
dc.language.isoenen_UK
dc.publisherSAGE Publicationsen_UK
dc.relationWaddell SJ, de Andrés MC, Tsimbouri PM, Alakpa EV, Cusack M, Dalby MJ & Oreffo ROC (2018) Biomimetic oyster shell–replicated topography alters the behaviour of human skeletal stem cells. Journal of Tissue Engineering, 9. https://doi.org/10.1177/2041731418794007en_UK
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en_UK
dc.subjectNacreen_UK
dc.subjecttopographyen_UK
dc.subjectskeletal stem cellen_UK
dc.subjectosteogenic differentiationen_UK
dc.subjectbone regenerationen_UK
dc.titleBiomimetic oyster shell–replicated topography alters the behaviour of human skeletal stem cellsen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1177/2041731418794007en_UK
dc.identifier.pmid30202512en_UK
dc.citation.jtitleJournal of Tissue Engineeringen_UK
dc.citation.issn2041-7314en_UK
dc.citation.issn2041-7314en_UK
dc.citation.volume9en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderUK Regenerative Medicine Platfromen_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.contributor.funderMedical Research Councilen_UK
dc.citation.date04/09/2018en_UK
dc.contributor.affiliationUniversity of Southamptonen_UK
dc.contributor.affiliationUniversity of Southamptonen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUmea Universityen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Southamptonen_UK
dc.identifier.isiWOS:000443733700001en_UK
dc.identifier.scopusid2-s2.0-85059332072en_UK
dc.identifier.wtid1031789en_UK
dc.contributor.orcid0000-0003-0145-1180en_UK
dc.date.accepted2018-07-19en_UK
dcterms.dateAccepted2018-07-19en_UK
dc.date.filedepositdate2018-10-11en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorWaddell, Shona J|en_UK
local.rioxx.authorde Andrés, María C|en_UK
local.rioxx.authorTsimbouri, Penelope M|en_UK
local.rioxx.authorAlakpa, Enateri V|en_UK
local.rioxx.authorCusack, Maggie|0000-0003-0145-1180en_UK
local.rioxx.authorDalby, Matthew J|en_UK
local.rioxx.authorOreffo, Richard O C|en_UK
local.rioxx.projectMR/K026682/1|UK Regenerative Medicine Platfrom|en_UK
local.rioxx.projectBB/L021072/1|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.projectBB/L00609X/1|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.projectMR/K011278/1|Medical Research Council|http://dx.doi.org/10.13039/501100000265en_UK
local.rioxx.freetoreaddate2018-10-11en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc/4.0/|2018-10-11|en_UK
local.rioxx.filename2041731418794007.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source2041-7314en_UK
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