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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Behavioral Fever Drives Epigenetic Modulation of the Immune Response in Fish
Author(s): Boltana, Sebastian
Aguilar, Andrea
Sanhueza, Nataly
Donoso, Andrea
Mercado, Luis
Imarai, Monica
Mackenzie, Simon
Keywords: behavioral fever
gene regulation
lymphocyte proliferation
cytokine release
epigenetic modification
Issue Date: 4-Jun-2018
Citation: Boltana S, Aguilar A, Sanhueza N, Donoso A, Mercado L, Imarai M & Mackenzie S (2018) Behavioral Fever Drives Epigenetic Modulation of the Immune Response in Fish. Frontiers in Immunology, 9, Art. No.: 1241.
Abstract: Ectotherms choose the best thermal conditions to mount a successful immune response, a phenomenon known as behavioral fever. The cumulative evidence suggests that behavioral fever impacts positively upon lymphocyte proliferation, inflammatory cytokine expression, and other immune functions. In this study, we have explored how thermal choice during infection impacts upon underpinning molecular processes and how temperature increase is coupled to the immune response. Our results show that behavioral fever results in a widespread, plastic imprint on gene regulation, and lymphocyte proliferation. We further explored the possible contribution of histone modification and identified global associations between temperature and histone changes that suggest epigenetic remodeling as a result of behavioral fever. Together, these results highlight the critical importance of thermal choice in mobile ectotherms, particularly in response to an infection, and demonstrate the key role of epigenetic modification to orchestrate the thermocoupling of the immune response during behavioral fever.
DOI Link: 10.3389/fimmu.2018.01241
Rights: © 2018 Boltana, Aguilar, Sanhueza, Donoso, Mercado, Imarai and Mackenzie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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