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dc.contributor.authorBoltana, Sebastianen_UK
dc.contributor.authorAguilar, Andreaen_UK
dc.contributor.authorSanhueza, Natalyen_UK
dc.contributor.authorDonoso, Andreaen_UK
dc.contributor.authorMercado, Luisen_UK
dc.contributor.authorImarai, Monicaen_UK
dc.contributor.authorMackenzie, Simonen_UK
dc.description.abstractEctotherms choose the best thermal conditions to mount a successful immune response, a phenomenon known as behavioral fever. The cumulative evidence suggests that behavioral fever impacts positively upon lymphocyte proliferation, inflammatory cytokine expression, and other immune functions. In this study, we have explored how thermal choice during infection impacts upon underpinning molecular processes and how temperature increase is coupled to the immune response. Our results show that behavioral fever results in a widespread, plastic imprint on gene regulation, and lymphocyte proliferation. We further explored the possible contribution of histone modification and identified global associations between temperature and histone changes that suggest epigenetic remodeling as a result of behavioral fever. Together, these results highlight the critical importance of thermal choice in mobile ectotherms, particularly in response to an infection, and demonstrate the key role of epigenetic modification to orchestrate the thermocoupling of the immune response during behavioral fever.en_UK
dc.publisherFrontiers Mediaen_UK
dc.relationBoltana S, Aguilar A, Sanhueza N, Donoso A, Mercado L, Imarai M & Mackenzie S (2018) Behavioral Fever Drives Epigenetic Modulation of the Immune Response in Fish. Frontiers in Immunology, 9, Art. No.: 1241.
dc.rights© 2018 Boltana, Aguilar, Sanhueza, Donoso, Mercado, Imarai and Mackenzie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_UK
dc.subjectbehavioral feveren_UK
dc.subjectgene regulationen_UK
dc.subjectlymphocyte proliferationen_UK
dc.subjectcytokine releaseen_UK
dc.subjectepigenetic modificationen_UK
dc.titleBehavioral Fever Drives Epigenetic Modulation of the Immune Response in Fishen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleFrontiers in Immunologyen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.contributor.affiliationPontifical Catholic University of Valparaisoen_UK
dc.contributor.affiliationUniversity of Santiagoen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
Appears in Collections:Aquaculture Journal Articles

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