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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults
Author(s): Parikh, Jehill
Thrippleton, Michael J
Murray, Catherine
Armitage, Paul A
Harris, Bridget A
Andrews, Peter J D
Wardlaw, Joanna M
Starr, John M
Deary, Ian J
Marshall, Ian
Keywords: MR spectroscopy
Brain metabolites
Basal ganglia
Older adults
Healthy volunteers
Issue Date: 30-Jun-2015
Citation: Parikh J, Thrippleton MJ, Murray C, Armitage PA, Harris BA, Andrews PJD, Wardlaw JM, Starr JM, Deary IJ & Marshall I (2015) Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults, Magnetic Resonance Materials in Physics, Biology and Medicine, 28 (3), pp. 251-257.
Abstract: Object We sought to measure brain metabolite levels in healthy older people. Materials and methods Spectroscopic imaging at the level of the basal ganglia was applied in 40 participants aged 73–74 years. Levels of the metabolites N-acetyl aspartate (NAA), choline, and creatine were determined in "institutional units" (IU) corrected for T1 and T2 relaxation effects. Structural imaging enabled determination of grey matter (GM), white matter (WM), and cerebrospinal fluid content. ANOVA analysis was carried out for voxels satisfying quality criteria. Results Creatine levels were greater in GM than WM (57 vs. 44 IU, p < 0.001), whereas choline and NAA levels were greater in WM than GM [13 vs. 10 IU (p < 0.001) and 76 versus 70 IU (p = 0.03), respectively]. The ratio of NAA/cre was greater in WM than GM (2.1 vs. 1.4, p = 0.001) as was that of cho/cre (0.32 vs. 0.16, p < 0.001). A low voxel yield was due to brain atrophy and the difficulties of shimming over an extended region of brain. Conclusion This study addresses the current lack of information on brain metabolite levels in older adults. The normal features of ageing result in a substantial loss of reliable voxels and should be taken into account when planning studies. Improvements in shimming are also required before the methods can be applied more widely.
DOI Link: 10.1007/s10334-014-0465-0
Rights: © The Author(s) 2014 This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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