Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27341
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dc.contributor.authorParikh, Jehillen_UK
dc.contributor.authorThrippleton, Michael Jen_UK
dc.contributor.authorMurray, Catherineen_UK
dc.contributor.authorArmitage, Paul Aen_UK
dc.contributor.authorHarris, Bridget Aen_UK
dc.contributor.authorAndrews, Peter J Den_UK
dc.contributor.authorWardlaw, Joanna Men_UK
dc.contributor.authorStarr, John Men_UK
dc.contributor.authorDeary, Ian Jen_UK
dc.contributor.authorMarshall, Ianen_UK
dc.date.accessioned2018-06-06T14:17:29Z-
dc.date.available2018-06-06T14:17:29Z-
dc.date.issued2015-06-30en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27341-
dc.description.abstractObject We sought to measure brain metabolite levels in healthy older people. Materials and methods Spectroscopic imaging at the level of the basal ganglia was applied in 40 participants aged 73–74 years. Levels of the metabolites N-acetyl aspartate (NAA), choline, and creatine were determined in "institutional units" (IU) corrected for T1 and T2 relaxation effects. Structural imaging enabled determination of grey matter (GM), white matter (WM), and cerebrospinal fluid content. ANOVA analysis was carried out for voxels satisfying quality criteria. Results Creatine levels were greater in GM than WM (57 vs. 44 IU, p < 0.001), whereas choline and NAA levels were greater in WM than GM [13 vs. 10 IU (p < 0.001) and 76 versus 70 IU (p = 0.03), respectively]. The ratio of NAA/cre was greater in WM than GM (2.1 vs. 1.4, p = 0.001) as was that of cho/cre (0.32 vs. 0.16, p < 0.001). A low voxel yield was due to brain atrophy and the difficulties of shimming over an extended region of brain. Conclusion This study addresses the current lack of information on brain metabolite levels in older adults. The normal features of ageing result in a substantial loss of reliable voxels and should be taken into account when planning studies. Improvements in shimming are also required before the methods can be applied more widely.en_UK
dc.language.isoenen_UK
dc.publisherSpringer Natureen_UK
dc.relationParikh J, Thrippleton MJ, Murray C, Armitage PA, Harris BA, Andrews PJD, Wardlaw JM, Starr JM, Deary IJ & Marshall I (2015) Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults, Magnetic Resonance Materials in Physics, Biology and Medicine, 28 (3), pp. 251-257. https://doi.org/10.1007/s10334-014-0465-0.en_UK
dc.rights© The Author(s) 2014 This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.en_UK
dc.subjectMR spectroscopyen_UK
dc.subjectBrain metabolitesen_UK
dc.subjectBasal gangliaen_UK
dc.subjectAgeingen_UK
dc.subjectOlder adultsen_UK
dc.subjectHealthy volunteersen_UK
dc.titleProton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adultsen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1007/s10334-014-0465-0en_UK
dc.citation.jtitleMagnetic Resonance Materials in Physics, Biology and Medicineen_UK
dc.citation.issn1352-8661en_UK
dc.citation.issn0968-5243en_UK
dc.citation.volume28en_UK
dc.citation.issue3en_UK
dc.citation.spage251en_UK
dc.citation.epage257en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.citation.date14/10/2014en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Sheffielden_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.wtid918546en_UK
dc.date.accepted2014-09-23en_UK
dc.date.firstcompliantdepositdate2018-06-06en_UK
dc.description.refREF Compliant by Deposit in Stirling's Repositoryen_UK
Appears in Collections:Psychology Journal Articles

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