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Appears in Collections:Computing Science and Mathematics Journal Articles
Peer Review Status: Refereed
Title: Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron
Author(s): Saudargiene, Ausra
Graham, Bruce
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Keywords: Spike-timing-dependent plasticity
CA1 pyramidal neuron
Dendritic spike
Inhibitory interneurons
Issue Date: Apr-2015
Date Deposited: 7-Jul-2016
Citation: Saudargiene A & Graham B (2015) Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron. Biosystems, 130, pp. 37-50.
Abstract: A computational model of a biochemical network underlying synaptic plasticity is combined with simulated on-going electrical activity in a model of a hippocampal pyramidal neuron to study the impact of synapse location and inhibition on synaptic plasticity. The simulated pyramidal neuron is activated by the realistic stimulation protocol of causal and anticausal spike pairings of presynaptic and postsynaptic action potentials in the presence and absence of spatially targeted inhibition provided by basket, bistratified and oriens-lacunosum moleculare (OLM) interneurons. The resulting Spike-timing-dependent plasticity (STDP) curves depend strongly on the number of pairing repetitions, the synapse location and the timing and strength of inhibition.
DOI Link: 10.1016/j.biosystems.2015.03.001
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