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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/23728
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dc.contributor.authorSaudargiene, Ausraen_UK
dc.contributor.authorGraham, Bruceen_UK
dc.date.accessioned2016-07-09T18:10:53Z-
dc.date.available2016-07-09T18:10:53Z-
dc.date.issued2015-04en_UK
dc.identifier.urihttp://hdl.handle.net/1893/23728-
dc.description.abstractA computational model of a biochemical network underlying synaptic plasticity is combined with simulated on-going electrical activity in a model of a hippocampal pyramidal neuron to study the impact of synapse location and inhibition on synaptic plasticity. The simulated pyramidal neuron is activated by the realistic stimulation protocol of causal and anticausal spike pairings of presynaptic and postsynaptic action potentials in the presence and absence of spatially targeted inhibition provided by basket, bistratified and oriens-lacunosum moleculare (OLM) interneurons. The resulting Spike-timing-dependent plasticity (STDP) curves depend strongly on the number of pairing repetitions, the synapse location and the timing and strength of inhibition.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationSaudargiene A & Graham B (2015) Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron. Biosystems, 130, pp. 37-50. https://doi.org/10.1016/j.biosystems.2015.03.001en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectSpike-timing-dependent plasticityen_UK
dc.subjectCA1 pyramidal neuronen_UK
dc.subjectDendritic spikeen_UK
dc.subjectInhibitory interneuronsen_UK
dc.titleInhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuronen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-11en_UK
dc.rights.embargoreason[Saudargiene_Graham_BioSystems_2015.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.biosystems.2015.03.001en_UK
dc.identifier.pmid25769669en_UK
dc.citation.jtitleBioSystemsen_UK
dc.citation.issn0303-2647en_UK
dc.citation.volume130en_UK
dc.citation.spage37en_UK
dc.citation.epage50en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailb.graham@cs.stir.ac.uken_UK
dc.citation.date10/03/2015en_UK
dc.contributor.affiliationVytautas Magnus Universityen_UK
dc.contributor.affiliationComputing Scienceen_UK
dc.identifier.isiWOS:000354502300005en_UK
dc.identifier.scopusid2-s2.0-84925337420en_UK
dc.identifier.wtid577652en_UK
dc.contributor.orcid0000-0002-3243-2532en_UK
dc.date.accepted2015-03-06en_UK
dcterms.dateAccepted2015-03-06en_UK
dc.date.filedepositdate2016-07-07en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorSaudargiene, Ausra|en_UK
local.rioxx.authorGraham, Bruce|0000-0002-3243-2532en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-11en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameSaudargiene_Graham_BioSystems_2015.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0303-2647en_UK
Appears in Collections:Computing Science and Mathematics Journal Articles

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