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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Zahedan rhabdovirus, a novel virus detected in ticks from Iran
Author(s): Dilcher, Meik
Faye, Oumar
Faye, Ousmane
Weber, Franziska
Koch, Andrea
Sadegh, Chinikar
Weidmann, Manfred
Sall, Amadou A
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Keywords: Zahedan rhabodovirus
Hyalomma anatolicum
Issue Date: Nov-2015
Date Deposited: 12-Nov-2015
Citation: Dilcher M, Faye O, Faye O, Weber F, Koch A, Sadegh C, Weidmann M & Sall AA (2015) Zahedan rhabdovirus, a novel virus detected in ticks from Iran. Virology Journal, 12 (1), Art. No.: 183.
Abstract: Background: Rhabdoviridaeinfect a wide range of vertebrates, invertebrates and plants. Their transmission can occur via various arthropod vectors. In recent years, a number of novel rhabdoviruses have been identified from various animal species, but so far only few tick-transmitted rhabdoviruses have been described.  Methods: We isolated a novel rhabdovirus, provisionally named Zahedan rhabdovirus (ZARV), fromHyalomma anatolicum anatolicumticks collected in Iran. The full-length genome was determined using 454 next-generation sequencing and the phylogenetic relationship to other rhabdoviruses was analyzed. Inoculation experiments in mammalian Vero cells and mice were conducted and a specific PCR assay was developed.  Results: The complete genome of ZARV has a size of 11,230 nucleotides (nt) with the typical genomic organization ofRhabdoviridae. Phylogenetic analysis confirms that ZARV is closely related to Moussa virus (MOUV) from West Africa and Long Island tick rhabdovirus (LITRV) from the U.S., all forming a new monophyletic clade, provisionally designatedZamolirhabdovirus, within theDimarhabdovirussupergroup. The glycoprotein (G) contains 12 conserved cysteins which are specific for animal rhabdoviruses infecting fish and mammals. In addition, ZARV is able to infect mammalian Vero cells and is lethal for mice when inoculated intracerebrally or subcutaneously. The developed PCR assay can be used to specifically detect ZARV.  Conclusion: The novel tick-transmitted rhabdovirus ZARV is closely related to MOUV and LITRV. All three viruses seem to form a new monophyletic clade. ZARV might be pathogenic for mammals, since it can infect Vero cells, is lethal for mice and its glycoprotein contains 12 conserved cysteins only found in animal rhabdoviruses. The mammalian host of ZARV remains to be identified.
DOI Link: 10.1186/s12985-015-0410-5
Rights: © 2015 Dilcher et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
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