Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22502
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dc.contributor.authorDilcher, Meiken_UK
dc.contributor.authorFaye, Oumaren_UK
dc.contributor.authorFaye, Ousmaneen_UK
dc.contributor.authorWeber, Franziskaen_UK
dc.contributor.authorKoch, Andreaen_UK
dc.contributor.authorSadegh, Chinikaren_UK
dc.contributor.authorWeidmann, Manfreden_UK
dc.contributor.authorSall, Amadou Aen_UK
dc.date.accessioned2015-11-30T23:20:42Z-
dc.date.available2015-11-30T23:20:42Z-
dc.date.issued2015-11en_UK
dc.identifier.other183en_UK
dc.identifier.urihttp://hdl.handle.net/1893/22502-
dc.description.abstractBackground: Rhabdoviridaeinfect a wide range of vertebrates, invertebrates and plants. Their transmission can occur via various arthropod vectors. In recent years, a number of novel rhabdoviruses have been identified from various animal species, but so far only few tick-transmitted rhabdoviruses have been described.  Methods: We isolated a novel rhabdovirus, provisionally named Zahedan rhabdovirus (ZARV), fromHyalomma anatolicum anatolicumticks collected in Iran. The full-length genome was determined using 454 next-generation sequencing and the phylogenetic relationship to other rhabdoviruses was analyzed. Inoculation experiments in mammalian Vero cells and mice were conducted and a specific PCR assay was developed.  Results: The complete genome of ZARV has a size of 11,230 nucleotides (nt) with the typical genomic organization ofRhabdoviridae. Phylogenetic analysis confirms that ZARV is closely related to Moussa virus (MOUV) from West Africa and Long Island tick rhabdovirus (LITRV) from the U.S., all forming a new monophyletic clade, provisionally designatedZamolirhabdovirus, within theDimarhabdovirussupergroup. The glycoprotein (G) contains 12 conserved cysteins which are specific for animal rhabdoviruses infecting fish and mammals. In addition, ZARV is able to infect mammalian Vero cells and is lethal for mice when inoculated intracerebrally or subcutaneously. The developed PCR assay can be used to specifically detect ZARV.  Conclusion: The novel tick-transmitted rhabdovirus ZARV is closely related to MOUV and LITRV. All three viruses seem to form a new monophyletic clade. ZARV might be pathogenic for mammals, since it can infect Vero cells, is lethal for mice and its glycoprotein contains 12 conserved cysteins only found in animal rhabdoviruses. The mammalian host of ZARV remains to be identified.en_UK
dc.language.isoenen_UK
dc.publisherBioMed Centralen_UK
dc.relationDilcher M, Faye O, Faye O, Weber F, Koch A, Sadegh C, Weidmann M & Sall AA (2015) Zahedan rhabdovirus, a novel virus detected in ticks from Iran. Virology Journal, 12 (1), Art. No.: 183. https://doi.org/10.1186/s12985-015-0410-5en_UK
dc.rights© 2015 Dilcher et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectZahedan rhabodovirusen_UK
dc.subjectZARVen_UK
dc.subjectTick-transmitteden_UK
dc.subjectHyalomma anatolicumen_UK
dc.subjectIranen_UK
dc.titleZahedan rhabdovirus, a novel virus detected in ticks from Iranen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1186/s12985-015-0410-5en_UK
dc.identifier.pmid26542354en_UK
dc.citation.jtitleVirology Journalen_UK
dc.citation.issn1743-422Xen_UK
dc.citation.volume12en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderEuropean Commissionen_UK
dc.author.emailm.w.weidmann@stir.ac.uken_UK
dc.citation.date05/11/2015en_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.identifier.isiWOS:000364375300001en_UK
dc.identifier.scopusid2-s2.0-84946566779en_UK
dc.identifier.wtid584613en_UK
dc.contributor.orcid0000-0002-7063-7491en_UK
dc.date.accepted2015-10-26en_UK
dcterms.dateAccepted2015-10-26en_UK
dc.date.filedepositdate2015-11-12en_UK
dc.relation.funderprojectCrimean Congo Hemorrhagic Fever; modern approaches to diagnostics, surveillance, prevention, therapy and preparednessen_UK
dc.relation.funderrefHEALTH-F3-2010-260427en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorDilcher, Meik|en_UK
local.rioxx.authorFaye, Oumar|en_UK
local.rioxx.authorFaye, Ousmane|en_UK
local.rioxx.authorWeber, Franziska|en_UK
local.rioxx.authorKoch, Andrea|en_UK
local.rioxx.authorSadegh, Chinikar|en_UK
local.rioxx.authorWeidmann, Manfred|0000-0002-7063-7491en_UK
local.rioxx.authorSall, Amadou A|en_UK
local.rioxx.projectHEALTH-F3-2010-260427|European Commission (Horizon 2020)|en_UK
local.rioxx.freetoreaddate2015-11-12en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2015-11-12|en_UK
local.rioxx.filenameDilcher et al_Virol J_2015.pdfen_UK
local.rioxx.filecount1en_UK
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