Please use this identifier to cite or link to this item:
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Molecular and serological findings in suspected patients with Crimean-Congo hemorrhagic fever virus in Iran
Author(s): Karlberg, Helen
Sharifi-Mood, Batool
Mousavi-Jazi, Mehrdad
Dilcher, Meik
Lindegren, Gunnel
Mardani, Masoud
Bereskly, Sandor
Weidmann, Manfred
Mirazimi, Ali
Contact Email:
Keywords: CCHF
neutralization assay
Issue Date: Apr-2015
Date Deposited: 27-Apr-2015
Citation: Karlberg H, Sharifi-Mood B, Mousavi-Jazi M, Dilcher M, Lindegren G, Mardani M, Bereskly S, Weidmann M & Mirazimi A (2015) Molecular and serological findings in suspected patients with Crimean-Congo hemorrhagic fever virus in Iran. Journal of Medical Virology, 87 (4), pp. 686-693.
Abstract: Crimean-Congo hemorrhagic fever (CCHF) is an arthropod-borne disease of humans associated with a severe clinical picture, including hemorrhagic syndrome and a high mortality rate. CCHF virus is widely distributed throughout large areas of the world. To characterize the serological status in CCHF patients, paired clinical samples were collected from suspected CCHF patients and analyzed by microbiological and other laboratory analyses with the aim of: determining the presence of neutralizing antibodies against CCHF virus; investigating the cross-reactivity of these neutralizing antibodies against virus isolated from the same outbreak and against other available laboratory strain; and studying the relationship between the isolated virus with other virus by whole genome sequencing. Patients at Boo-Ali Hospital, Zahedan, Iran, with clinical symptoms ranging from mild to severe hemorrhagic fever were included in the study. Two serum samples were taken from each patient, the first as soon as the patient matched the criteria for CCHF notification and the second when the patient was discharged from hospital (2 weeks later). Commercial and in-house assays revealed a positive IgM signal in acute serum samples from six patients. A novel finding was that CCHF patients develop neutralizing antibodies soon after infection. Interestingly these antibodies were able to neutralize other CCHF virus strains too. The complete sequence of the Zahedan 2007 isolate, including the hitherto unknown first L-segment sequence, was identified using an original clinical sample from one patient with confirmed CCHF infection.
DOI Link: 10.1002/jmv.24106
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Licence URL(s):

Files in This Item:
File Description SizeFormat 
Karlberg_et_al-2015-Journal_of_Medical_Virology.pdfFulltext - Published Version510.04 kBAdobe PDFUnder Permanent Embargo    Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.