Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21709
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dc.contributor.authorKarlberg, Helenen_UK
dc.contributor.authorSharifi-Mood, Batoolen_UK
dc.contributor.authorMousavi-Jazi, Mehrdaden_UK
dc.contributor.authorDilcher, Meiken_UK
dc.contributor.authorLindegren, Gunnelen_UK
dc.contributor.authorMardani, Masouden_UK
dc.contributor.authorBereskly, Sandoren_UK
dc.contributor.authorWeidmann, Manfreden_UK
dc.contributor.authorMirazimi, Alien_UK
dc.date.accessioned2015-05-16T02:07:51Z-
dc.date.available2015-05-16T02:07:51Z-
dc.date.issued2015-04en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21709-
dc.description.abstractCrimean-Congo hemorrhagic fever (CCHF) is an arthropod-borne disease of humans associated with a severe clinical picture, including hemorrhagic syndrome and a high mortality rate. CCHF virus is widely distributed throughout large areas of the world. To characterize the serological status in CCHF patients, paired clinical samples were collected from suspected CCHF patients and analyzed by microbiological and other laboratory analyses with the aim of: determining the presence of neutralizing antibodies against CCHF virus; investigating the cross-reactivity of these neutralizing antibodies against virus isolated from the same outbreak and against other available laboratory strain; and studying the relationship between the isolated virus with other virus by whole genome sequencing. Patients at Boo-Ali Hospital, Zahedan, Iran, with clinical symptoms ranging from mild to severe hemorrhagic fever were included in the study. Two serum samples were taken from each patient, the first as soon as the patient matched the criteria for CCHF notification and the second when the patient was discharged from hospital (2 weeks later). Commercial and in-house assays revealed a positive IgM signal in acute serum samples from six patients. A novel finding was that CCHF patients develop neutralizing antibodies soon after infection. Interestingly these antibodies were able to neutralize other CCHF virus strains too. The complete sequence of the Zahedan 2007 isolate, including the hitherto unknown first L-segment sequence, was identified using an original clinical sample from one patient with confirmed CCHF infection.en_UK
dc.language.isoenen_UK
dc.publisherWiley-Blackwellen_UK
dc.relationKarlberg H, Sharifi-Mood B, Mousavi-Jazi M, Dilcher M, Lindegren G, Mardani M, Bereskly S, Weidmann M & Mirazimi A (2015) Molecular and serological findings in suspected patients with Crimean-Congo hemorrhagic fever virus in Iran. Journal of Medical Virology, 87 (4), pp. 686-693. https://doi.org/10.1002/jmv.24106en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectCCHFen_UK
dc.subjectdiagnosticen_UK
dc.subjectserologyen_UK
dc.subjectneutralization assayen_UK
dc.titleMolecular and serological findings in suspected patients with Crimean-Congo hemorrhagic fever virus in Iranen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[Karlberg_et_al-2015-Journal_of_Medical_Virology.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1002/jmv.24106en_UK
dc.citation.jtitleJournal of Medical Virologyen_UK
dc.citation.issn1096-9071en_UK
dc.citation.issn0146-6615en_UK
dc.citation.volume87en_UK
dc.citation.issue4en_UK
dc.citation.spage686en_UK
dc.citation.epage693en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderEuropean Commissionen_UK
dc.author.emailm.w.weidmann@stir.ac.uken_UK
dc.contributor.affiliationKarolinska Instituteten_UK
dc.contributor.affiliationZahedan University of Medical Sciencesen_UK
dc.contributor.affiliationPublic Health Agency of Swedenen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationPublic Health Agency of Swedenen_UK
dc.contributor.affiliationShahid Beheshti University of Medical Sciencesen_UK
dc.contributor.affiliationPublic Health Agency of Swedenen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationSwedish Institute for Infectious Disease Controlen_UK
dc.identifier.isiWOS:000349299500020en_UK
dc.identifier.scopusid2-s2.0-84922955950en_UK
dc.identifier.wtid601774en_UK
dc.contributor.orcid0000-0002-7063-7491en_UK
dc.date.accepted2014-09-09en_UK
dcterms.dateAccepted2014-09-09en_UK
dc.date.filedepositdate2015-04-27en_UK
dc.relation.funderprojectCrimean Congo Hemorrhagic Fever; modern approaches to diagnostics, surveillance, prevention, therapy and preparednessen_UK
dc.relation.funderrefHEALTH-F3-2010-260427en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorKarlberg, Helen|en_UK
local.rioxx.authorSharifi-Mood, Batool|en_UK
local.rioxx.authorMousavi-Jazi, Mehrdad|en_UK
local.rioxx.authorDilcher, Meik|en_UK
local.rioxx.authorLindegren, Gunnel|en_UK
local.rioxx.authorMardani, Masoud|en_UK
local.rioxx.authorBereskly, Sandor|en_UK
local.rioxx.authorWeidmann, Manfred|0000-0002-7063-7491en_UK
local.rioxx.authorMirazimi, Ali|en_UK
local.rioxx.projectHEALTH-F3-2010-260427|European Commission (Horizon 2020)|en_UK
local.rioxx.freetoreaddate2999-12-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameKarlberg_et_al-2015-Journal_of_Medical_Virology.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0146-6615en_UK
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