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STORRE: Stirling Online Research Repository
http://hdl.handle.net/1893/19305| Appears in Collections: | Biological and Environmental Sciences Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Diverse Immune Functions of Hemocyanins |
| Author(s): | Coates, Christopher Nairn, Jacqueline |
| Contact Email: | c.j.coates@stir.ac.uk |
| Keywords: | Multifunctional Hemocyanin Phenoloxidase Microbicidal Innate immunity Hemoglobin |
| Issue Date: | Jul-2014 |
| Date Deposited: | 26-Feb-2014 |
| Citation: | Coates C & Nairn J (2014) Diverse Immune Functions of Hemocyanins. Developmental and Comparative Immunology, 45 (1), pp. 43-55. https://doi.org/10.1016/j.dci.2014.01.021 |
| Abstract: | Substantial evidence gathered recently has revealed the multiple functionalities of hemocyanin. Contrary to previous claims that this ancient protein is involved solely in oxygen transport within the hemolymph of invertebrates, hemocyanin and hemocyanin-derived peptides have been linked to key aspects of innate immunity, in particular, antiviral and phenoloxidase-like activities. Both phenoloxidase and hemocyanin belong to the family of type-3 copper proteins and share a high degree of sequence homology. While the importance of phenoloxidase in immunity and development is well characterised, the contribution of hemocyanin to biological defence systems within invertebrates is not recognised widely. This review focusses on the conversion of hemocyanin into a phenoloxidase-like enzyme and the array of hemocyanin-derived immune responses documented to date. |
| DOI Link: | 10.1016/j.dci.2014.01.021 |
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| Licence URL(s): | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved |
| File | Description | Size | Format | |
|---|---|---|---|---|
| 8_Coates and Nairn 2014 Devel Comp Immunol.pdf | Fulltext - Published Version | 2.6 MB | Adobe PDF | Under Embargo until 3000-01-01 Request a copy |
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