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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Genetics of sex determination in tilapiine species
Author(s): Cnaani, Avner
Lee, Bo-Young
Zilberman, Noam
Ozouf-Costaz, Catherine
Hulata, Gideon
Ron, Micha
D’Hont, Angelique
Baroiller, Jean-Francois
D’Cotta, Helena
Penman, David
Tomasino, Elizabeth
Coutanceau, Jean-Pierre
Pepey, Elodie
Shirak, Andrey
Kocher, Thomas D
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Keywords: Cichlidae
heterogametic sex
recombination suppression
sex chromosome
sex determination
Issue Date: Apr-2008
Citation: Cnaani A, Lee B, Zilberman N, Ozouf-Costaz C, Hulata G, Ron M, D’Hont A, Baroiller J, D’Cotta H, Penman D, Tomasino E, Coutanceau J, Pepey E, Shirak A & Kocher TD (2008) Genetics of sex determination in tilapiine species, Sexual Development, 2 (1), pp. 43-54.
Abstract: We identified DNA markers linked to sex determining genes in six closely related species of tilapiine fishes. The mode of sex determination differed among species. In Oreochromis karongae and Tilapia mariae the sex-determining locus is on linkage group (LG) 3 and the female is heterogametic (WZ-ZZ system). In O. niloticus and T. zillii the sex-determining locus is on LG1 and the male is heterogametic (XX-XY system). A more complex pattern was observed in O. aureus and O. mossambicus, in which markers on both LG1 and LG3 were associated with sex. We found evidence for sex-linked lethal effects on LG1, as well as interactions between loci in the two linkage groups. Comparison of genetic and physical maps demonstrated a broad region of recombination suppression harboring the sex-determining locus on LG3. Sex-specific recombination suppression was found in the female heterogametic sex. Sequence analysis showed the accumulation of repetitive elements in this region. Phylogenetic analysis suggests that at least two transitions in the mode of sex determination have occurred in this clade. This variation in sex determination mechanisms among closely related species makes tilapias an excellent model system for studying the evolution of sex chromosomes in vertebrates.
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