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dc.contributor.authorCnaani, Avner-
dc.contributor.authorLee, Bo-Young-
dc.contributor.authorZilberman, Noam-
dc.contributor.authorOzouf-Costaz, Catherine-
dc.contributor.authorHulata, Gideon-
dc.contributor.authorRon, Micha-
dc.contributor.authorD’Hont, Angelique-
dc.contributor.authorBaroiller, Jean-Francois-
dc.contributor.authorD’Cotta, Helena-
dc.contributor.authorPenman, David-
dc.contributor.authorTomasino, Elizabeth-
dc.contributor.authorCoutanceau, Jean-Pierre-
dc.contributor.authorPepey, Elodie-
dc.contributor.authorShirak, Andrey-
dc.contributor.authorKocher, Thomas D-
dc.description.abstractWe identified DNA markers linked to sex determining genes in six closely related species of tilapiine fishes. The mode of sex determination differed among species. In Oreochromis karongae and Tilapia mariae the sex-determining locus is on linkage group (LG) 3 and the female is heterogametic (WZ-ZZ system). In O. niloticus and T. zillii the sex-determining locus is on LG1 and the male is heterogametic (XX-XY system). A more complex pattern was observed in O. aureus and O. mossambicus, in which markers on both LG1 and LG3 were associated with sex. We found evidence for sex-linked lethal effects on LG1, as well as interactions between loci in the two linkage groups. Comparison of genetic and physical maps demonstrated a broad region of recombination suppression harboring the sex-determining locus on LG3. Sex-specific recombination suppression was found in the female heterogametic sex. Sequence analysis showed the accumulation of repetitive elements in this region. Phylogenetic analysis suggests that at least two transitions in the mode of sex determination have occurred in this clade. This variation in sex determination mechanisms among closely related species makes tilapias an excellent model system for studying the evolution of sex chromosomes in vertebrates.en_UK
dc.relationCnaani A, Lee B, Zilberman N, Ozouf-Costaz C, Hulata G, Ron M, D’Hont A, Baroiller J, D’Cotta H, Penman D, Tomasino E, Coutanceau J, Pepey E, Shirak A & Kocher TD (2008) Genetics of sex determination in tilapiine species, Sexual Development, 2 (1), pp. 43-54.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectheterogametic sexen_UK
dc.subjectrecombination suppressionen_UK
dc.subjectsex chromosomeen_UK
dc.subjectsex determinationen_UK
dc.subject.lcshTilapia Genetics-
dc.subject.lcshSex determination, Genetic-
dc.subject.lcshSex Chromosomes genetics-
dc.titleGenetics of sex determination in tilapiine speciesen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonI do not have the final authors' version of this article. The document submitted is the final journal article, and the embargo should be permanent for copyright reasons. Anyone wanting a copy can request it from me. The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleSexual Development-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationVirginia Polytechnic Institute And State University-
dc.contributor.affiliationUniversity of Maryland-
dc.contributor.affiliationAgricultural Research Organization (ARO)-
dc.contributor.affiliationMuseum National d’Histoire Naturelle-
dc.contributor.affiliationAgricultural Research Organization (ARO)-
dc.contributor.affiliationAgricultural Research Organization (ARO)-
dc.contributor.affiliationCornell University-
dc.contributor.affiliationMuseum National d’Histoire Naturelle-
dc.contributor.affiliationAgricultural Research Organization (ARO)-
dc.contributor.affiliationUniversity of Maryland-
Appears in Collections:Aquaculture Journal Articles

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