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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Treatment with an aromatase inhibitor suppresses high-temperature feminization of genetic male (YY) Nile tilapia
Author(s): Kwon, Joon Yeong
McAndrew, Brendan
Penman, David
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Keywords: genetic sex determination
temperature-dependent sex determination
sexual differentiation
Oreochromis niloticus
Fishes Sexing
Fishes Genetics
Fishes Sex ratio
Fishes Reproduction
Issue Date: Mar-2002
Date Deposited: 9-Nov-2012
Citation: Kwon JY, McAndrew B & Penman D (2002) Treatment with an aromatase inhibitor suppresses high-temperature feminization of genetic male (YY) Nile tilapia. Journal of Fish Biology, 60 (3), pp. 625-636.
Abstract: High temperature (36° C) treatment during sexual differentiation caused significant changes in sex ratio in YY male Nile tilapia Oreochromis niloticus fry (64.5% males compared to 100.0% males at 28° C), while dietary treatment with a chemical aromatase inhibitor (AI: FadrozoleTM CGS16949A) during this period suppressed the high temperature feminization (98.9% males). This implies that cytochrome P450 aromatase is mechanistically associated with temperature-dependent sex determination (TSD) in this species. XY male fry did not show significant sex reversal at 36° C. In XX female fry, high temperature treatment resulted in significant masculinization (62.5% males compared with 21.9% males at 28° C), while treatment with AI at either temperature resulted in very high proportions of males (100.0% males at 36° C; 99.0% males at 28° C). These results confirm the importance of aromatase in sexual differentiation in the Nile tilapia below the TSD threshold and suggest that it also plays a role in TSD, at least in the YY genotype.
DOI Link: 10.1111/j.1095-8649.2002.tb01689.x
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