|Appears in Collections:||Aquaculture Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Treatment with an aromatase inhibitor suppresses high-temperature feminization of genetic male (YY) Nile tilapia|
|Author(s):||Kwon, Joon Yeong|
|Keywords:||genetic sex determination|
temperature-dependent sex determination
|Citation:||Kwon JY, McAndrew B & Penman D (2002) Treatment with an aromatase inhibitor suppresses high-temperature feminization of genetic male (YY) Nile tilapia, Journal of Fish Biology, 60 (3), pp. 625-636.|
|Abstract:||High temperature (36° C) treatment during sexual differentiation caused significant changes in sex ratio in YY male Nile tilapia Oreochromis niloticus fry (64.5% males compared to 100.0% males at 28° C), while dietary treatment with a chemical aromatase inhibitor (AI: FadrozoleTM CGS16949A) during this period suppressed the high temperature feminization (98.9% males). This implies that cytochrome P450 aromatase is mechanistically associated with temperature-dependent sex determination (TSD) in this species. XY male fry did not show significant sex reversal at 36° C. In XX female fry, high temperature treatment resulted in significant masculinization (62.5% males compared with 21.9% males at 28° C), while treatment with AI at either temperature resulted in very high proportions of males (100.0% males at 36° C; 99.0% males at 28° C). These results confirm the importance of aromatase in sexual differentiation in the Nile tilapia below the TSD threshold and suggest that it also plays a role in TSD, at least in the YY genotype.|
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