Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/35156
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dc.contributor.authorCopplestone, Daviden_UK
dc.contributor.authorCoates, Christopher Jen_UK
dc.contributor.authorLim, Jensonen_UK
dc.date.accessioned2023-05-30T00:03:30Z-
dc.date.available2023-05-30T00:03:30Z-
dc.date.issued2023-06-10en_UK
dc.identifier.other162742en_UK
dc.identifier.urihttp://hdl.handle.net/1893/35156-
dc.description.abstractLarvae of the greater wax moth Galleria mellonella are common pests of beehives and commercial apiaries, and in more applied settings, these insects act as alternative in vivo bioassays to rodents for studying microbial virulence, antibiotic development, and toxicology. In the current study, our aim was to assess the putative adverse effects of background gamma radiation levels on G. mellonella. To achieve this, we exposed larvae to low (0.014 mGy/h), medium (0.056 mGy/h), and high (1.33 mGy/h) doses of caesium-137 and measured larval pupation events, weight, faecal discharge, susceptibility to bacterial and fungal challenges, immune cell counts, activity, and viability (i.e., haemocyte encapsulation) and melanisation levels. The effects of low and medium levels of radiation were distinguishable from the highest dose rates used – the latter insects weighed the least and pupated earlier. In general, radiation exposure modulated cellular and humoral immunity over time, with larvae showing heightened encapsulation/melanisation levels at the higher dose rates but were more susceptible to bacterial (Photorhabdus luminescens) infection. There were few signs of radiation impacts after 7 days exposure, whereas marked changes were recorded between 14 and 28 days. Our data suggest that G. mellonella demonstrates plasticity at the whole organism and cellular levels when irradiated and offers insight into how such animals may cope in radiologically contaminated environments (e.g. Chornobyl Exclusion Zone).en_UK
dc.language.isoenen_UK
dc.publisherElsevier BVen_UK
dc.relationCopplestone D, Coates CJ & Lim J (2023) Low dose γ-radiation induced effects on wax moth (Galleria mellonella) larvae. <i>Science of The Total Environment</i>, 876, Art. No.: 162742. https://doi.org/10.1016/j.scitotenv.2023.162742en_UK
dc.rightsThis is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectCaesium-137en_UK
dc.subjectHaemocytesen_UK
dc.subjectInnate immunityen_UK
dc.subjectCellular defence reactionsen_UK
dc.subjectMelanisationen_UK
dc.subjectImuunotoxicologyen_UK
dc.titleLow dose γ-radiation induced effects on wax moth (Galleria mellonella) larvaeen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.scitotenv.2023.162742en_UK
dc.identifier.pmid36906041en_UK
dc.citation.jtitleScience of the Total Environmenten_UK
dc.citation.issn1879-1026en_UK
dc.citation.issn0048-9697en_UK
dc.citation.volume876en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderThe Carnegie Trusten_UK
dc.author.emailjenson.lim@stir.ac.uken_UK
dc.citation.date10/03/2023en_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.contributor.affiliationSwansea Universityen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.identifier.isiWOS:000957677800001en_UK
dc.identifier.scopusid2-s2.0-85150387009en_UK
dc.identifier.wtid1887778en_UK
dc.contributor.orcid0000-0002-1468-9545en_UK
dc.contributor.orcid0000-0001-7417-356Xen_UK
dc.date.accepted2023-03-05en_UK
dcterms.dateAccepted2023-03-05en_UK
dc.date.filedepositdate2023-04-25en_UK
dc.relation.funderprojectEvaluating the impact of chronic exposure to low dose ionising radiation on immunityen_UK
dc.relation.funderrefRIG008296en_UK
dc.subject.tagBiology: Molecularen_UK
dc.subject.tagEnvironmental Radioactivityen_UK
dc.subject.tagRadioecologyen_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorCopplestone, David|0000-0002-1468-9545en_UK
local.rioxx.authorCoates, Christopher J|en_UK
local.rioxx.authorLim, Jenson|0000-0001-7417-356Xen_UK
local.rioxx.projectRIG008296|The Carnegie Trust|en_UK
local.rioxx.freetoreaddate2023-04-25en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2023-04-25|en_UK
local.rioxx.filename1-s2.0-S004896972301358X-main.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1879-1026en_UK
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