Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21124
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: A systematic review and meta-analysis
Authors: Morris, Dylan
Rodriguez, Alexander
Moxon, Joseph V
Cunningham, Margaret
McDermott, Mary
Myers, Jonathan
Leeper, Nicholas
Jones, Rhondda
Golledge, Jonathan
Contact Email: mc52@stir.ac.uk
Keywords: lower extremity performance
mortality
peripheral artery disease
Issue Date: 13-Aug-2014
Publisher: American Heart Association
Citation: Morris D, Rodriguez A, Moxon JV, Cunningham M, McDermott M, Myers J, Leeper N, Jones R & Golledge J (2014) Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: A systematic review and meta-analysis, Journal of the American Heart Association, 3 (4), Art. No.: e001105.
Abstract: Background: Peripheral artery disease (PAD) is associated with impaired mobility and a high rate of mortality. The aim of this systematic review was to investigate whether reduced lower extremity performance was associated with an increased incidence of cardiovascular and all‐cause mortality in people with PAD. Methods and Results: A systematic search of the MEDLINE, EMBASE, SCOPUS, Web of Science, and Cochrane Library databases was conducted. Studies assessing the association between measures of lower extremity performance and cardiovascular or all‐cause mortality in PAD patients were included. A meta‐analysis was conducted combining data from commonly assessed performance tests. The 10 identified studies assessed lower extremity performance by strength tests, treadmill walking performance, 6‐minute walk, walking velocity, and walking impairment questionnaire (WIQ). A meta‐analysis revealed that shorter maximum walking distance was associated with increased 5‐year cardiovascular (unadjusted RR=2.54, 95% CI 1.86 to 3.47, P<10−5, n=1577, fixed effects) and all‐cause mortality (unadjusted RR=2.23 95% CI 1.85 to 2.69, P<10−5, n=1710, fixed effects). Slower 4‐metre walking velocity, a lower WIQ stair‐climbing score, and poor hip extension, knee flexion, and plantar flexion strength were also associated with increased mortality. No significant associations were found for hip flexion strength, WIQ distance score, or WIQ speed score with mortality. Conclusions: A number of lower extremity performance measures are prognostic markers for mortality in PAD and may be useful clinical tools for identifying patients at higher risk of death. Further studies are needed to determine whether interventions that improve measures of lower extremity performance reduce mortality.
Type: Journal Article
URI: http://hdl.handle.net/1893/21124
DOI Link: http://dx.doi.org/10.1161/JAHA.114.001105
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: James Cook University
James Cook University
James Cook University
Psychology
Northwestern University
Stanford University
Stanford University
James Cook University
James Cook University

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