Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21124
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dc.contributor.authorMorris, Dylanen_UK
dc.contributor.authorRodriguez, Alexanderen_UK
dc.contributor.authorMoxon, Joseph Ven_UK
dc.contributor.authorCunningham, Margareten_UK
dc.contributor.authorMcDermott, Maryen_UK
dc.contributor.authorMyers, Jonathanen_UK
dc.contributor.authorLeeper, Nicholasen_UK
dc.contributor.authorJones, Rhonddaen_UK
dc.contributor.authorGolledge, Jonathanen_UK
dc.date.accessioned2017-06-10T00:13:31Z-
dc.date.available2017-06-10T00:13:31Z-
dc.date.issued2014-08-13en_UK
dc.identifier.othere001105en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21124-
dc.description.abstractBackground: Peripheral artery disease (PAD) is associated with impaired mobility and a high rate of mortality. The aim of this systematic review was to investigate whether reduced lower extremity performance was associated with an increased incidence of cardiovascular and all‐cause mortality in people with PAD. Methods and Results: A systematic search of the MEDLINE, EMBASE, SCOPUS, Web of Science, and Cochrane Library databases was conducted. Studies assessing the association between measures of lower extremity performance and cardiovascular or all‐cause mortality in PAD patients were included. A meta‐analysis was conducted combining data from commonly assessed performance tests. The 10 identified studies assessed lower extremity performance by strength tests, treadmill walking performance, 6‐minute walk, walking velocity, and walking impairment questionnaire (WIQ). A meta‐analysis revealed that shorter maximum walking distance was associated with increased 5‐year cardiovascular (unadjusted RR=2.54, 95% CI 1.86 to 3.47, P<10−5, n=1577, fixed effects) and all‐cause mortality (unadjusted RR=2.23 95% CI 1.85 to 2.69, P<10−5, n=1710, fixed effects). Slower 4‐metre walking velocity, a lower WIQ stair‐climbing score, and poor hip extension, knee flexion, and plantar flexion strength were also associated with increased mortality. No significant associations were found for hip flexion strength, WIQ distance score, or WIQ speed score with mortality. Conclusions: A number of lower extremity performance measures are prognostic markers for mortality in PAD and may be useful clinical tools for identifying patients at higher risk of death. Further studies are needed to determine whether interventions that improve measures of lower extremity performance reduce mortality.en_UK
dc.language.isoenen_UK
dc.publisherAmerican Heart Associationen_UK
dc.relationMorris D, Rodriguez A, Moxon JV, Cunningham M, McDermott M, Myers J, Leeper N, Jones R & Golledge J (2014) Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: A systematic review and meta-analysis. Journal of the American Heart Association, 3 (4), Art. No.: e001105. https://doi.org/10.1161/JAHA.114.001105en_UK
dc.rights© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en_UK
dc.subjectlower extremity performanceen_UK
dc.subjectmortalityen_UK
dc.subjectperipheral artery diseaseen_UK
dc.titleAssociation of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: A systematic review and meta-analysisen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1161/JAHA.114.001105en_UK
dc.identifier.pmid25122666en_UK
dc.citation.jtitleJournal of the American Heart Associationen_UK
dc.citation.issn2047-9980en_UK
dc.citation.volume3en_UK
dc.citation.issue4en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailmc52@stir.ac.uken_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationNorthwestern Universityen_UK
dc.contributor.affiliationStanford Universityen_UK
dc.contributor.affiliationStanford Universityen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.identifier.isiWOS:000341296600059en_UK
dc.identifier.scopusid2-s2.0-84939461886en_UK
dc.identifier.wtid617681en_UK
dc.contributor.orcid0000-0002-5850-9825en_UK
dc.date.accepted2014-07-14en_UK
dcterms.dateAccepted2014-07-14en_UK
dc.date.filedepositdate2014-09-30en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMorris, Dylan|en_UK
local.rioxx.authorRodriguez, Alexander|en_UK
local.rioxx.authorMoxon, Joseph V|en_UK
local.rioxx.authorCunningham, Margaret|0000-0002-5850-9825en_UK
local.rioxx.authorMcDermott, Mary|en_UK
local.rioxx.authorMyers, Jonathan|en_UK
local.rioxx.authorLeeper, Nicholas|en_UK
local.rioxx.authorJones, Rhondda|en_UK
local.rioxx.authorGolledge, Jonathan|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2014-09-30en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc/4.0/|2014-09-30|en_UK
local.rioxx.filenameMorris 2014.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source2047-9980en_UK
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