Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19744
Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Acquired immunity protects against helminth infection in a natural host population: Long-term field and laboratory evidence
Authors: Tinsley, Richard C
Stott, Lucy C
York, Jenny E
Everard, Amy L E
Chapple, Sara J
Jackson, Joseph
Viney, Mark
Tinsley, M C
Contact Email: matthew.tinsley@stir.ac.uk
Issue Date: Sep-2012
Publisher: Elsevier
Citation: Tinsley RC, Stott LC, York JE, Everard ALE, Chapple SJ, Jackson J, Viney M & Tinsley MC (2012) Acquired immunity protects against helminth infection in a natural host population: Long-term field and laboratory evidence, International Journal for Parasitology, 42 (10), pp. 931-938.
Abstract: Long-term records of parasite infection are rare for individuals in wild host populations. This study, on an introduced population of Xenopus laevis in Wales, demonstrates powerful control by acquired immunity of the monogenean, Protopolystoma xenopodis. Field evidence was based on a 10 year dataset for 619 individually-marked hosts screened at each capture for patent (egg-producing) infection. The adult parasite population occurred predominantly in juvenile hosts. Invasion began rapidly ‘post-birth' (in early tadpoles). Longitudinal records for animals aged ⩾15 years showed that, after loss of this primary infection, most hosts had strong resistance to re-infection. For ca. 80% of the population, no infections were recorded during adult life; for ca. 15%, there were isolated brief episodes of patent infection; for ca. 5%, parasites persisted as repeated short-term or chronic long-term infections. Acquired immunity was confirmed by laboratory challenge infection of wild-caught X. laevis: in 30/32 exposures, no parasites survived to maturity; in the two infected, development was retarded. Parasite persistence depends principally on host recruitment generating naïve young (as in human measles). In some hosts, retarded parasite development delays reproduction for several years: these infections show ‘Typhoid Mary' characteristics, persisting in ‘latent' form with potential to initiate epidemics in naïve cohorts.
Type: Journal Article
URI: http://hdl.handle.net/1893/19744
DOI Link: http://dx.doi.org/10.1016/j.ijpara.2012.07.006
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Bristol
University of Bristol
University of Bristol
University of Bristol
University of Bristol
Aberystwyth University
University of Bristol
Biological and Environmental Sciences

Files in This Item:
File Description SizeFormat 
IJP 2012.pdf322.35 kBAdobe PDFUnder Embargo until 31/12/2999     Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.

This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.