Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19744
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dc.contributor.authorTinsley, Richard Cen_UK
dc.contributor.authorStott, Lucy Cen_UK
dc.contributor.authorYork, Jenny Een_UK
dc.contributor.authorEverard, Amy L Een_UK
dc.contributor.authorChapple, Sara Jen_UK
dc.contributor.authorJackson, Josephen_UK
dc.contributor.authorViney, Marken_UK
dc.contributor.authorTinsley, M Cen_UK
dc.date.accessioned2014-04-05T23:09:59Z-
dc.date.available2014-04-05T23:09:59Zen_UK
dc.date.issued2012-09en_UK
dc.identifier.urihttp://hdl.handle.net/1893/19744-
dc.description.abstractLong-term records of parasite infection are rare for individuals in wild host populations. This study, on an introduced population of Xenopus laevis in Wales, demonstrates powerful control by acquired immunity of the monogenean, Protopolystoma xenopodis. Field evidence was based on a 10 year dataset for 619 individually-marked hosts screened at each capture for patent (egg-producing) infection. The adult parasite population occurred predominantly in juvenile hosts. Invasion began rapidly ‘post-birth' (in early tadpoles). Longitudinal records for animals aged ⩾15 years showed that, after loss of this primary infection, most hosts had strong resistance to re-infection. For ca. 80% of the population, no infections were recorded during adult life; for ca. 15%, there were isolated brief episodes of patent infection; for ca. 5%, parasites persisted as repeated short-term or chronic long-term infections. Acquired immunity was confirmed by laboratory challenge infection of wild-caught X. laevis: in 30/32 exposures, no parasites survived to maturity; in the two infected, development was retarded. Parasite persistence depends principally on host recruitment generating naïve young (as in human measles). In some hosts, retarded parasite development delays reproduction for several years: these infections show ‘Typhoid Mary' characteristics, persisting in ‘latent' form with potential to initiate epidemics in naïve cohorts.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationTinsley RC, Stott LC, York JE, Everard ALE, Chapple SJ, Jackson J, Viney M & Tinsley MC (2012) Acquired immunity protects against helminth infection in a natural host population: Long-term field and laboratory evidence. International Journal for Parasitology, 42 (10), pp. 931-938. https://doi.org/10.1016/j.ijpara.2012.07.006en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleAcquired immunity protects against helminth infection in a natural host population: Long-term field and laboratory evidenceen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[IJP 2012.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.ijpara.2012.07.006en_UK
dc.citation.jtitleInternational Journal for Parasitologyen_UK
dc.citation.issn0020-7519en_UK
dc.citation.volume42en_UK
dc.citation.issue10en_UK
dc.citation.spage931en_UK
dc.citation.epage938en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailmatthew.tinsley@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationAberystwyth Universityen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.identifier.isiWOS:000309991500007en_UK
dc.identifier.scopusid2-s2.0-84865573811en_UK
dc.identifier.wtid762262en_UK
dc.contributor.orcid0000-0002-7715-1259en_UK
dcterms.dateAccepted2012-09-30en_UK
dc.date.filedepositdate2014-04-03en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorTinsley, Richard C|en_UK
local.rioxx.authorStott, Lucy C|en_UK
local.rioxx.authorYork, Jenny E|en_UK
local.rioxx.authorEverard, Amy L E|en_UK
local.rioxx.authorChapple, Sara J|en_UK
local.rioxx.authorJackson, Joseph|en_UK
local.rioxx.authorViney, Mark|en_UK
local.rioxx.authorTinsley, M C|0000-0002-7715-1259en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameIJP 2012.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0020-7519en_UK
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