Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/10094
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: A single photon emission computerised tomography study of regional brain fuction underlying verbal memory in patients with Alzheimer-type dementia
Authors: Riddle, William J
O'Carroll, Ronan
Dougall, Nadine
Van, Beck Margaret
Murray, Caroline M
Curran, S M
Ebmeier, Klaus P
Goodwin, Guy M
Contact Email: ronan.ocarroll@stir.ac.uk
Issue Date: Aug-1993
Publisher: The Royal College of Psychiatrists
Citation: Riddle WJ, O'Carroll R, Dougall N, Van Beck M, Murray CM, Curran SM, Ebmeier KP & Goodwin GM (1993) A single photon emission computerised tomography study of regional brain fuction underlying verbal memory in patients with Alzheimer-type dementia, British Journal of Psychiatry, 163 (2), pp. 166-172.
Abstract: Ten patients with Alzheimer-type dementia and nine age-matched normal controls were examined with SPECT, using split-dose 99mTc-labelled exametazime. The baseline condition involved repetition of the word 'yes' or 'no'. The activation condition involved recognition (indicated by a 'yes' or 'no') of words from a previously learned list presented along with distractor words. Patients who performed this task successfully were selected, and efforts were made to match the patients with controls according to their performance on the task, although this was not fully achieved. Uptake of 99mTc-exametazime was estimated at baseline and during the word-recognition task for predetermined regions of interest drawn from a standard neuroanatomical atlas. The baseline task appeared to normalise tracer uptake for frontal, temporal and parietal cortex in the patient group. However, during the recognition task, controls but not patients showed activation effects. These were most prominent in dorsolateral frontal cortex and adjacent anterior cingulate cortex. Among patients, successful performance was correlated with activation of dorsolateral frontal and parietal cortex on the left side. The results confirm the central role of frontal mechanisms in a recognition memory task. The study highlights some of the difficulties of using cognitive challenge tests in clinical groups.
Type: Journal Article
URI: http://hdl.handle.net/1893/10094
DOI Link: http://dx.doi.org/10.1192/bjp.163.2.166
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Royal Edinburgh Hospital
Psychology
NMAHP Research
Royal Edinburgh Hospital
Royal Edinburgh Hospital
Royal Edinburgh Hospital
Royal Edinburgh Hospital
Royal Edinburgh Hospital

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