Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/10094
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dc.contributor.authorRiddle, William Jen_UK
dc.contributor.authorO'Carroll, Ronanen_UK
dc.contributor.authorDougall, Nadineen_UK
dc.contributor.authorVan Beck, Margareten_UK
dc.contributor.authorMurray, Caroline Men_UK
dc.contributor.authorCurran, S Men_UK
dc.contributor.authorEbmeier, Klaus Pen_UK
dc.contributor.authorGoodwin, Guy Men_UK
dc.date.accessioned2014-09-14T15:46:11Z-
dc.date.available2014-09-14T15:46:11Zen_UK
dc.date.issued1993-08en_UK
dc.identifier.urihttp://hdl.handle.net/1893/10094-
dc.description.abstractTen patients with Alzheimer-type dementia and nine age-matched normal controls were examined with SPECT, using split-dose 99mTc-labelled exametazime. The baseline condition involved repetition of the word 'yes' or 'no'. The activation condition involved recognition (indicated by a 'yes' or 'no') of words from a previously learned list presented along with distractor words. Patients who performed this task successfully were selected, and efforts were made to match the patients with controls according to their performance on the task, although this was not fully achieved. Uptake of 99mTc-exametazime was estimated at baseline and during the word-recognition task for predetermined regions of interest drawn from a standard neuroanatomical atlas. The baseline task appeared to normalise tracer uptake for frontal, temporal and parietal cortex in the patient group. However, during the recognition task, controls but not patients showed activation effects. These were most prominent in dorsolateral frontal cortex and adjacent anterior cingulate cortex. Among patients, successful performance was correlated with activation of dorsolateral frontal and parietal cortex on the left side. The results confirm the central role of frontal mechanisms in a recognition memory task. The study highlights some of the difficulties of using cognitive challenge tests in clinical groups.en_UK
dc.language.isoenen_UK
dc.publisherThe Royal College of Psychiatristsen_UK
dc.relationRiddle WJ, O'Carroll R, Dougall N, Van Beck M, Murray CM, Curran SM, Ebmeier KP & Goodwin GM (1993) A single photon emission computerised tomography study of regional brain fuction underlying verbal memory in patients with Alzheimer-type dementia. British Journal of Psychiatry, 163 (2), pp. 166-172. https://doi.org/10.1192/bjp.163.2.166en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleA single photon emission computerised tomography study of regional brain fuction underlying verbal memory in patients with Alzheimer-type dementiaen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Riddle et al_BJP_1993.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1192/bjp.163.2.166en_UK
dc.citation.jtitleBritish Journal of Psychiatryen_UK
dc.citation.issn1472-1465en_UK
dc.citation.issn0007-1250en_UK
dc.citation.volume163en_UK
dc.citation.issue2en_UK
dc.citation.spage166en_UK
dc.citation.epage172en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailronan.ocarroll@stir.ac.uken_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationNMAHPen_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.identifier.scopusid2-s2.0-0027270942en_UK
dc.identifier.wtid747150en_UK
dc.contributor.orcid0000-0002-5130-291Xen_UK
dc.contributor.orcid0000-0003-3462-6960en_UK
dcterms.dateAccepted1993-08-31en_UK
dc.date.filedepositdate2012-12-05en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorRiddle, William J|en_UK
local.rioxx.authorO'Carroll, Ronan|0000-0002-5130-291Xen_UK
local.rioxx.authorDougall, Nadine|0000-0003-3462-6960en_UK
local.rioxx.authorVan Beck, Margaret|en_UK
local.rioxx.authorMurray, Caroline M|en_UK
local.rioxx.authorCurran, S M|en_UK
local.rioxx.authorEbmeier, Klaus P|en_UK
local.rioxx.authorGoodwin, Guy M|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameRiddle et al_BJP_1993.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0007-1250en_UK
Appears in Collections:Psychology Journal Articles

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