|Appears in Collections:||Management, Work and Organisation Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Heredity Links Natural Hazards and Human Health: Apolipoprotein E Gene Moderates the Health of Earthquake Survivors|
gene X environment interaction
|Citation:||Daly M & MacLachlan M (2011) Heredity Links Natural Hazards and Human Health: Apolipoprotein E Gene Moderates the Health of Earthquake Survivors, Health Psychology, 30 (2), pp. 228-235.|
|Abstract:||Objective: This study aimed to investigate the role of the apolipoprotein ε4 allele in moderating the influence of an exogenous stressor, an earthquake, on health. Design: A "natural experiment" design was used where the interaction between the presence of the apolipoprotein ε4 allele and the level of subjective and objective exposure to a devastating earthquake was examined in a population-based cohort of elderly Taiwanese (N =718). Main Outcome Measures: The cognitive-affective dimension of health was assessed by measures of perceived control and depression and functional limitations were assessed using measures of instrumental activities of daily living and mobility. Overall health status was gauged using a single-item measure of self-rated health. Results: Those who experienced damage to their property or were forced to move from their homes (high objective exposure) demonstrated low levels of self-rated health and somewhat lower perceived control a year later, only if they were apolipoprotein ε4 carriers. Similarly, those who found the earthquake severely distressing (high subjective exposure) were shown to have low levels of functioning and low self-rated health a year later, only if they possessed the ε4 allele. Conclusion: Our findings suggest that genetic variation in the apolipoprotein E gene may modify the health effects of the exogenous stress of natural disaster exposure.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Heredity Links Natural Hazards and Human Health_11.pdf||188.19 kB||Adobe PDF||Under Permanent Embargo Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.