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dc.contributor.authorChan, Man-Suenen_UK
dc.contributor.authorSrividya, AdiNarayananen_UK
dc.contributor.authorNorman, Rachelen_UK
dc.contributor.authorPani, S Pen_UK
dc.contributor.authorRamaiah, Kapa Den_UK
dc.contributor.authorVanamail, Perumalen_UK
dc.contributor.authorMichael, Edwinen_UK
dc.contributor.authorDas, Pradeep Ken_UK
dc.contributor.authorBundy, Don A Pen_UK
dc.description.abstractThe lack of a quantitative framework that describes the dynamic relationships between infection and morbidity has constrained efforts aimed at the community-level control of lymphatic filariasis. In this paper, we describe the development and validation of EPIFIL, a dynamic model of filariasis infection intensity and chronic disease. Infection dynamics are modeled using the well established immigration-death formulation, incorporating the acquisition of immunity to infective larvae over time. The dynamics of disease (lymphodema and hydrocele) are modeled as a catalytic function of a variety of factors, including worm load and the impact of immunopathological responses. The model was parameterized using age-stratified data collected from a Bancroftian filariasis endemic area in Pondicherry in southern India. The fitted parameters suggest that a relatively simple model including only acquired immunity to infection and irreversible progression to disease can satisfactorily explain the observed infection and disease patterns. Disease progression is assumed to be a consequence of worm induced damage and to occur at a high rate for hydrocele and a low rate for lymphodema. This suggests that immunopathology involvement may not be a necessary component of observed age-disease profiles. These findings support a central role for worm burden in the initiation and progression of chronic filarial disease.en_UK
dc.publisherAmerican Society of Tropical Medicine and Hygieneen_UK
dc.relationChan M, Srividya A, Norman R, Pani SP, Ramaiah KD, Vanamail P, Michael E, Das PK & Bundy DAP (1998) Epifil: a dynamic model of infection and disease in lymphatic filariasis. American Journal of Tropical Medicine and Hygiene, 59 (4), pp. 606-614.
dc.rightsPublisher policy allows this work to be made available in this repository. Published in American Journal of Tropical Medicine and Hygiene October 1998 vol. 59 no. 4, pp. 606-614 by [publisher]. The original publication is available at
dc.titleEpifil: a dynamic model of infection and disease in lymphatic filariasisen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleAmerican Journal of Tropical Medicine and Hygieneen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationVector Control Research Centreen_UK
dc.contributor.affiliationVector Control Research Centreen_UK
dc.contributor.affiliationVector Control Research Centreen_UK
dc.contributor.affiliationVector Control Research Centreen_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationVector Control Research Centreen_UK
dc.contributor.affiliationUniversity of Oxforden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorChan, Man-Suen|en_UK
local.rioxx.authorSrividya, AdiNarayanan|en_UK
local.rioxx.authorNorman, Rachel|0000-0002-7398-6064en_UK
local.rioxx.authorPani, S P|en_UK
local.rioxx.authorRamaiah, Kapa D|en_UK
local.rioxx.authorVanamail, Perumal|en_UK
local.rioxx.authorMichael, Edwin|en_UK
local.rioxx.authorDas, Pradeep K|en_UK
local.rioxx.authorBundy, Don A P|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Computing Science and Mathematics Journal Articles

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