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dc.contributor.authorGrubb, Neil Ren_UK
dc.contributor.authorFox, Keith A Aen_UK
dc.contributor.authorSmith, Karenen_UK
dc.contributor.authorBest, Jonathan J Ken_UK
dc.contributor.authorBlane, Annetteen_UK
dc.contributor.authorEbmeier, Klaus Pen_UK
dc.contributor.authorGlabus, Michael Fen_UK
dc.contributor.authorO'Carroll, Ronanen_UK
dc.description.abstractBackground and Purpose -- More than 30% of out-of-hospital cardiac arrest (OHCA) survivors suffer significant memory impairment. The hippocampus may be vulnerable to hypoxic injury during cardiac arrest. The purpose of this study was to determine whether selective hippocampal injury is the substrate for this memory impairment. Methods -- Seventeen OHCA survivors and 12 patients with uncomplicated myocardial infarction were studied. OHCA survivors were divided into those with impaired and intact memory. Memory was assessed by use of the Rivermead Behavioural Memory Test and Doors and People Test. MRI was used to determine intracranial, whole-brain, amygdala-hippocampal complex, and temporal lobe volumes. Brain structure was also examined by statistical parametric mapping. Results -- Left amygdala-hippocampal volume was reduced in memory-impaired OHCA victims compared with control subjects (mean 3.93 cm3 and 95% CI 3.50 to 4.36 cm3 versus mean 4.65 cm3 and 95% CI 4.37 to 4.93 cm3; P=0.002). Left temporal lobe and whole-brain volumes were also reduced. There were no differences in amygdala-hippocampal volume indexed against ipsilateral temporal lobe volume. Significant correlations were observed between total brain volume and Rivermead Behavioural Memory Test (r=0.56, P less than 0.05) and Doors and People Test (r=0.67, P less than 0.01) scores in OHCA survivors. Both recall and recognition were compromised in memory-impaired subjects. Statistical parametric mapping did not detect focal brain abnormalities in these subjects. Global cerebral atrophy was confirmed by qualitative assessment. Conclusions -- Memory impairment in OHCA survivors is associated with global cerebral atrophy, not selective hippocampal damage. Rehabilitation protocols need to account for the global nature of the brain injury.en_UK
dc.publisherAmerican Heart Associationen_UK
dc.relationGrubb NR, Fox KAA, Smith K, Best JJK, Blane A, Ebmeier KP, Glabus MF & O'Carroll R (2000) Memory impairment in out-of-hospital cardiac arrest survivors is associated with global reduction in brain volume, not focal hippocampal injury. Stroke, 31 (7), pp. 1509-1514.;
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectheart arresten_UK
dc.subjectmagnetic resonance imagingen_UK
dc.titleMemory impairment in out-of-hospital cardiac arrest survivors is associated with global reduction in brain volume, not focal hippocampal injuryen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[ocarroll_Stroke_2000.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationRoyal Infirmary of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorGrubb, Neil R|en_UK
local.rioxx.authorFox, Keith A A|en_UK
local.rioxx.authorSmith, Karen|en_UK
local.rioxx.authorBest, Jonathan J K|en_UK
local.rioxx.authorBlane, Annette|en_UK
local.rioxx.authorEbmeier, Klaus P|en_UK
local.rioxx.authorGlabus, Michael F|en_UK
local.rioxx.authorO'Carroll, Ronan|0000-0002-5130-291Xen_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Psychology Journal Articles

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