Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCalton, Jeffrey Len_UK
dc.contributor.authorStackman, Robert Wen_UK
dc.contributor.authorGoodridge, Jeremy Pen_UK
dc.contributor.authorArchey, William Ben_UK
dc.contributor.authorDudchenko, Paulen_UK
dc.contributor.authorTaube, Jeffrey Sen_UK
dc.description.abstractThe occurrence of cells that encode spatial location (place cells) or head direction (HD cells) in the rat limbic system suggests that these cell types are important for spatial navigation. We sought to determine whether place fields of hippocampal CA1 place cells would be altered in animals receiving lesions of brain areas containing HD cells. Rats received bilateral lesions of anterodorsal thalamic nuclei (ADN), postsubiculum (PoS), or sham lesions, before place cell recording. Although place cells from lesioned animals did not differ from controls on many place-field characteristics, such as place-field size and infield firing rate, the signal was significantly degraded with respect to measures of outfield firing rate, spatial coherence, and information content. Surprisingly, place cells from lesioned animals were more likely modulated by the directional heading of the animal. Rotation of the landmark cue showed that place fields from PoS-lesioned animals were not controlled by the cue and shifted unpredictably between sessions. Although fields from ADN-lesioned animals tended to have less landmark control than fields from control animals, this impairment was mild compared with cells recorded from PoS-lesioned animals. Removal of the prominent visual cue also led to instability of place-field representations in PoS-lesioned, but not ADN-lesioned, animals. Together, these findings suggest that an intact HD system is not necessary for the maintenance of place fields, but lesions of brain areas that convey the HD signal can degrade this signal, and lesions of the PoS might lead to perceptual or mnemonic deficits, leading to place-field instability between sessions.en_UK
dc.publisherSociety for Neuroscienceen_UK
dc.relationCalton JL, Stackman RW, Goodridge JP, Archey WB, Dudchenko P & Taube JS (2003) Hippocampal Place Cell Instability after Lesions of the Head Direction Cell Network. Journal of Neuroscience, 23 (30), pp. 9719-9731.
dc.rightsPublisher allows this work to be made available in this repository. Published in The Journal of Neuroscience by Society for Neuroscience with the following policy: Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license. The original publication is available at
dc.subjectPath integrationen_UK
dc.subjectAnterodorsal thalamic nucleusen_UK
dc.subjectSpatial orientationen_UK
dc.titleHippocampal Place Cell Instability after Lesions of the Head Direction Cell Networken_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleJournal of Neuroscienceen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationDartmouth Collegeen_UK
dc.contributor.affiliationDartmouth Collegeen_UK
dc.contributor.affiliationDartmouth Collegeen_UK
dc.contributor.affiliationDartmouth Collegeen_UK
dc.contributor.affiliationDartmouth Collegeen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorCalton, Jeffrey L|en_UK
local.rioxx.authorStackman, Robert W|en_UK
local.rioxx.authorGoodridge, Jeremy P|en_UK
local.rioxx.authorArchey, William B|en_UK
local.rioxx.authorDudchenko, Paul|0000-0002-1531-5713en_UK
local.rioxx.authorTaube, Jeffrey S|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Psychology Journal Articles

Files in This Item:
File Description SizeFormat 
Dudchenko_2003_Hippocampal_Place_Cell_Instability.pdfFulltext - Published Version777.47 kBAdobe PDFView/Open

This item is protected by original copyright

A file in this item is licensed under a Creative Commons License Creative Commons

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.