Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8740
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBekaert, Michaël-
dc.contributor.authorBidou, Laure-
dc.contributor.authorDenise, Alain-
dc.contributor.authorDuchateau-Nguyen, Guillemette-
dc.contributor.authorForest, Jean-Paul-
dc.contributor.authorFroidevaux, Christine-
dc.contributor.authorHatin, Isabelle-
dc.contributor.authorRousset, Jean-Pierre-
dc.contributor.authorTermier, Michel-
dc.date.accessioned2014-10-30T00:03:00Z-
dc.date.issued2003-02-12-
dc.identifier.urihttp://hdl.handle.net/1893/8740-
dc.description.abstractMotivation: Unconventional decoding events are now well acknowledged, but not yet well formalized. In this study, we present a bioinformatics analysis of eukaryotic −1 frameshifting, in order to model this event. Results: A consensus model has already been established for -1 frameshifting sites. Our purpose here is to provide new constraints which make the model more precise. We show how a machine learning approach can be used to refine the current model. We identify new properties that may be involved in frameshifting. Each of the properties found was experimentally validated. Initially, we identify features of the overall model that are to be simultaneously satisfied. We then focus on the following two components: the spacer and the slippery sequence. As a main result, we point out that the identity of the primary structure of the so-called spacer is of great importance.en_UK
dc.language.isoen-
dc.publisherOxford University Press-
dc.relationBekaert M, Bidou L, Denise A, Duchateau-Nguyen G, Forest J, Froidevaux C, Hatin I, Rousset J & Termier M (2003) Towards a computational model for-1 eukaryotic frameshifting sites, Bioinformatics, 19 (3), pp. 327-335.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.titleTowards a computational model for-1 eukaryotic frameshifting sitesen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1093/bioinformatics/btf868-
dc.citation.jtitleBioinformatics-
dc.citation.issn1367-4803-
dc.citation.volume19-
dc.citation.issue3-
dc.citation.spage327-
dc.citation.epage335-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailmichael.bekaert@stir.ac.uk-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationInstitute of Genetics and Microbiology, France-
dc.contributor.affiliationInstitute of Genetics and Microbiology, France-
dc.contributor.affiliationInstitute of Genetics and Microbiology, France-
dc.contributor.affiliationUniversity of Paris 11 (University of Paris Sud)-
dc.contributor.affiliationUniversity of Paris 11 (University of Paris Sud)-
dc.contributor.affiliationInstitute of Genetics and Microbiology, France-
dc.contributor.affiliationInstitute of Genetics and Microbiology, France-
dc.contributor.affiliationInstitute of Genetics and Microbiology, France-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000181303000002-
Appears in Collections:Aquaculture Journal Articles

Files in This Item:
File Description SizeFormat 
Bekaert_Towards_a_computational_model_2003.pdf128.45 kBAdobe PDFUnder Permanent Embargo    Request a copy


This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.