STORRE
STORRE: Stirling Online Research Repository
http://hdl.handle.net/1893/8733| Appears in Collections: | Aquaculture Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Bactericidal synergy of lysostaphin in combination with antimicrobial peptides |
| Author(s): | Desbois, Andrew P Coote, Peter J |
| Contact Email: | andrew.desbois@stir.ac.uk |
| Issue Date: | Aug-2011 |
| Date Deposited: | 31-Aug-2012 |
| Citation: | Desbois AP & Coote PJ (2011) Bactericidal synergy of lysostaphin in combination with antimicrobial peptides. European Journal of Clinical Microbiology and Infectious Diseases, 30 (8), pp. 1015-1021. https://doi.org/10.1007/s10096-011-1188-z |
| Abstract: | Drug-resistant staphylococci constitute a serious problem that urgently requires the discovery of new therapeutic agents. There has been a resurgence in interest in using lysostaphin (a specific anti-staphylococcal enzyme) as a treatment for infections caused by these important pathogens. However, bacterial resistance to lysostaphin is a problem, but the use of a combination treatment may surmount this issue. In this present study, using viable counts from suspension incubations, lysostaphin is shown to be synergistically bactericidal in combination with various conventional antimicrobial peptides, the antimicrobial protein bovine lactoferrin, a lantibiotic (nisin), and certain lipopeptides used clinically (colistin, daptomycin and polymyxin B). Combinations that act in synergy are of clinical importance as these reduce the doses of the compounds needed for effective treatments and decrease the chances of resistance being selected. The use of lysostaphin in combination with a peptide may represent a new avenue in tackling drug-resistant staphylococci. |
| DOI Link: | 10.1007/s10096-011-1188-z |
| Rights: | The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. |
| Licence URL(s): | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved |
| File | Description | Size | Format | |
|---|---|---|---|---|
| desboisandcoote_eurjclinmicrobiolinfect_2011.pdf | Fulltext - Published Version | 126.82 kB | Adobe PDF | Under Embargo until 3000-01-01 Request a copy |
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright |
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved https://creativecommons.org/publicdomain/zero/1.0/
If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.