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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Survey of small antifungal peptides with chemotherapeutic potential
Author(s): Desbois, Andrew P
Tschorner, David
Coote, Peter J
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Keywords: Antimicrobial peptides
Candida albicans
drug resistance
mechanism of action
potent antifungal activity
mammalian cell toxicity
Chemotherapeutic Potential
antifungal activity
Antifungal Peptides
Issue Date: Aug-2011
Date Deposited: 31-Aug-2012
Citation: Desbois AP, Tschorner D & Coote PJ (2011) Survey of small antifungal peptides with chemotherapeutic potential. Current Pharmaceutical Biotechnology, 12 (8), pp. 1263-1291.
Abstract: Many cationic peptides with antimicrobial properties have been isolated from bacteria, fungi, plants, and animals. These peptides vary in molecular size, potency and spectra of activities. This report surveyed the literature to highlight the peptides that have antifungal activity and greatest potential for development as new therapeutic agents. Thus, to be included in the evaluation, each peptide had to fulfil the following criteria: (i) potent antifungal activity, (ii) no, or minimal, mammalian cell toxicity, (iii) of ≤25 amino acids in length, which minimises the costs of synthesis, reduces immunogenicity and enhances bioavailability and stability in vivo, (iv) minimal post-translational modifications (also reduces the production costs). The ∼80 peptides that satisfied these criteria are discussed with respect to their structures, mechanisms of antimicrobial action and in vitro and in vivo toxicities. Certainly, some of these small peptides warrant further study and have potential for future exploitation as new antifungal agents.
DOI Link: 10.2174/138920111796117265
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