|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Postexercise net protein synthesis in human muscle from orally administered amino acids|
Ferrando, Arny A
Phillips, Stuart M
Doyle, David J
Wolfe, Robert R
|Keywords:||muscle protein synthesis|
muscle protein breakdown
|Citation:||Tipton K, Ferrando AA, Phillips SM, Doyle DJ & Wolfe RR (1999) Postexercise net protein synthesis in human muscle from orally administered amino acids, American Journal of Physiology - Endocrinology and Metabolism, 276 (4), pp. E628-E634.|
|Abstract:||We examined the response of net muscle protein synthesis to ingestion of amino acids after a bout of resistance exercise. A primed, constant infusion ofl-[ring-2H5]phenylalanine was used to measure net muscle protein balance in three male and three female volunteers on three occasions. Subjects consumed in random order 1 liter of 1) a mixed amino acid (40 g) solution (MAA), 2) an essential amino acid (40 g) solution (EAA), and3) a placebo solution (PLA). Arterial amino acid concentrations increased ∼150-640% above baseline during ingestion of MAA and EAA. Net muscle protein balance was significantly increased from negative during PLA ingestion (-50 ± 23 nmol ⋅ min-1 ⋅ 100 ml leg volume-1) to positive during MAA ingestion (17 ± 13 nmol ⋅ min-1 ⋅ 100 ml leg volume-1) and EAA (29 ± 14 nmol ⋅ min-1 ⋅ 100 ml leg volume-1;P less than 0.05). Because net balance was similar for MAA and EAA, it does not appear necessary to include nonessential amino acids in a formulation designed to elicit an anabolic response from muscle after exercise. We concluded that ingestion of oral essential amino acids results in a change from net muscle protein degradation to net muscle protein synthesis after heavy resistance exercise in humans similar to that seen when the amino acids were infused.|
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