Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTipton, Kevinen_UK
dc.contributor.authorFerrando, Arny Aen_UK
dc.contributor.authorPhillips, Stuart Men_UK
dc.contributor.authorDoyle, David Jen_UK
dc.contributor.authorWolfe, Robert Ren_UK
dc.description.abstractWe examined the response of net muscle protein synthesis to ingestion of amino acids after a bout of resistance exercise. A primed, constant infusion ofl-[ring-2H5]phenylalanine was used to measure net muscle protein balance in three male and three female volunteers on three occasions. Subjects consumed in random order 1 liter of 1) a mixed amino acid (40 g) solution (MAA), 2) an essential amino acid (40 g) solution (EAA), and3) a placebo solution (PLA). Arterial amino acid concentrations increased ∼150-640% above baseline during ingestion of MAA and EAA. Net muscle protein balance was significantly increased from negative during PLA ingestion (-50 ± 23 nmol ⋅ min-1 ⋅ 100 ml leg volume-1) to positive during MAA ingestion (17 ± 13 nmol ⋅ min-1 ⋅ 100 ml leg volume-1) and EAA (29 ± 14 nmol ⋅ min-1 ⋅ 100 ml leg volume-1;P less than 0.05). Because net balance was similar for MAA and EAA, it does not appear necessary to include nonessential amino acids in a formulation designed to elicit an anabolic response from muscle after exercise. We concluded that ingestion of oral essential amino acids results in a change from net muscle protein degradation to net muscle protein synthesis after heavy resistance exercise in humans similar to that seen when the amino acids were infused.en_UK
dc.publisherThe American Physiological Societyen_UK
dc.relationTipton K, Ferrando AA, Phillips SM, Doyle DJ & Wolfe RR (1999) Postexercise net protein synthesis in human muscle from orally administered amino acids. American Journal of Physiology - Endocrinology and Metabolism, 276 (4), pp. E628-E634.
dc.rightsThe publisher has not responded to our queries therefore this work cannot be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectmuscle protein synthesisen_UK
dc.subjectmuscle protein breakdownen_UK
dc.subjectresistance exerciseen_UK
dc.subjectstable isotopesen_UK
dc.titlePostexercise net protein synthesis in human muscle from orally administered amino acidsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[E628.full.pdf] The publisher has not responded to our queries. This work cannot be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleAmerican journal of physiology. Endocrinology and metabolismen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Texasen_UK
dc.contributor.affiliationUniversity of Texasen_UK
dc.contributor.affiliationUniversity of Texasen_UK
dc.contributor.affiliationUniversity of Texasen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.authorFerrando, Arny A|en_UK
local.rioxx.authorPhillips, Stuart M|en_UK
local.rioxx.authorDoyle, David J|en_UK
local.rioxx.authorWolfe, Robert R|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

Files in This Item:
File Description SizeFormat 
E628.full.pdfFulltext - Published Version207.75 kBAdobe PDFUnder Permanent Embargo    Request a copy

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.