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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver
Author(s): Pirrit, Lindsay A
Healey, R
Assheton, H
Leaver, Michael
George, Stephen
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Issue Date: 1995
Date Deposited: 29-Aug-2012
Citation: Pirrit LA, Healey R, Assheton H, Leaver M & George S (1995) Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver. Marine Environmental Research, 39 (1-4), pp. 15-19.;
Abstract: cDNA's coding for cytochrome P4501A1 (CYP1A1), phenol UDP-glucuronosyltransferase (UDPGT) and glutathione S-transferase (GST-A) were cloned and sequenced from an expression library prepared from the liver of a 3-methylcholanthrene (3-MC) induced plaice. Plaice CYP1A1 and Phenol UDPGT display a high degree of structural conservation with homologous mammalian isoforms and their mRNAs were shown to be highly induced in liver after 3-MC treatment of fish. Expression of plaice GST-A, which displays closer homology to GSTs from plants and invertebrates than those of mammals, is repressed after 3-MC treatment.
DOI Link: 10.1016/0141-1136(94)00065-W
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