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dc.contributor.authorBoukouvala, Evridikien_UK
dc.contributor.authorAntonopoulou, Efthimiaen_UK
dc.contributor.authorFavre-Krey, Laurenceen_UK
dc.contributor.authorDiez, Amaliaen_UK
dc.contributor.authorBautista, Jose Men_UK
dc.contributor.authorLeaver, Michaelen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorKrey, Grigoriosen_UK
dc.description.abstractPeroxisome proliferator-activated receptors (PPAR) are nuclear hormone receptors that control the expression of genes involved in lipid homeostasis in mammals. We searched for PPAR in sea bass, a marine fish of particular interest to aquaculture, after hypothesizing that the physiological and molecular processes that regulate lipid metabolism in fish are similar to those in mammals. Here, we report the identification of complementary DNA and corresponding genomic sequences that encode three distinct PPAR from sea bass. The sea bass PPAR are the structural homologs of the mammalian PPARα, β/δ and γ isotypes. As revealed by RNase protection, the tissue expression profile of the fish PPAR appears to be very similar to that of the mammalian PPAR homologs. Thus, PPARα is mainly expressed in the liver, PPARγ in adipose tissue, and PPARβ in all tissues tested, with its highest levels in the liver, where it is also the dominant isotype expressed. Like mammalian PPAR, the sea bass isotypes recognize and bind to PPAR response elements of both mammalian and piscine origin, as heterodimers with the 9-cis retinoic acid receptor. Through the coactivator-dependent receptor ligand assay, we also demonstrated that natural FA and synthetic hypolipidemic compounds can act as ligands of the sea bass PPARα and β isotypes. This suggests that the sea bass PPAR act through similar mechanisms and perform the same critical lipid metabolism functions as mammalian PPAR.en_UK
dc.relationBoukouvala E, Antonopoulou E, Favre-Krey L, Diez A, Bautista JM, Leaver M, Tocher DR & Krey G (2004) Molecular characterization of three peroxisome proliferator-activated receptors from the sea bass (Dicentrarchus labrax). Lipids, 39 (11), pp. 1085-1092.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.titleMolecular characterization of three peroxisome proliferator-activated receptors from the sea bass (Dicentrarchus labrax)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[tocher_lipids39_2004.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationNational Agricultural Research Foundationen_UK
dc.contributor.affiliationNational Agricultural Research Foundationen_UK
dc.contributor.affiliationNational Agricultural Research Foundationen_UK
dc.contributor.affiliationUniversidad Complutense de Madriden_UK
dc.contributor.affiliationUniversidad Complutense de Madriden_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationNational Agricultural Research Foundationen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorBoukouvala, Evridiki|en_UK
local.rioxx.authorAntonopoulou, Efthimia|en_UK
local.rioxx.authorFavre-Krey, Laurence|en_UK
local.rioxx.authorDiez, Amalia|en_UK
local.rioxx.authorBautista, Jose M|en_UK
local.rioxx.authorLeaver, Michael|0000-0002-3155-0844en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorKrey, Grigorios|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Aquaculture Journal Articles

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