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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7630

Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: A peroxisomal proliferator-activated receptor gene from the marine flatfish, the plaice (Pleuronectes platessa)
Author(s): Leaver, Michael
Wright, Joy
George, Stephen
Contact Email: m.j.leaver@stir.ac.uk
Issue Date: Jul-1998
Publisher: Elsevier
Citation: Leaver M, Wright J & George S (1998) A peroxisomal proliferator-activated receptor gene from the marine flatfish, the plaice (Pleuronectes platessa), Marine Environmental Research, 46 (1-5), pp. 75-79.
Abstract: Recently we have shown that glutathione S-transferase (GST) genes from a marine flatfish, plaice, are up-regulated after administration of peroxisome proliferators (PPs), and the products of these genes are efficient in the conjugation of some of the end-products of lipid peroxidation. The promoters of these genes contain sequence elements identical to peroxisome proliferator- activated receptor (PPAR)-response elements in mammals, thus linking the control of lipid metabolism with mechanisms for detoxifying peroxidised lipids. Since widespread chemical contaminants such as industrial plasticisers and pesticides are PPs, the regulation of genes which might be involved in detoxifying the effects of these chemicals is of great interest. In order to further study the regulation of these GST genes we have isolated a plaice PPAR gene and here we describe its structure and initial characterisation. The role of PPs in regulating plaice GST genes which are involved in the detoxification of peroxidised lipids will also be discussed.
Type: Journal Article
URI: http://hdl.handle.net/1893/7630
URL: http://www.sciencedirect.com/science/article/pii/S0141113697000706
DOI Link: http://dx.doi.org/10.1016/S0141-1136(97)00070-6
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
University of Stirling
Aquaculture

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