Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLeaver, Michael-
dc.contributor.authorBoukouvala, Evridiki-
dc.contributor.authorAntonopoulou, Efthimia-
dc.contributor.authorDiez, Amalia-
dc.contributor.authorFavre-Krey, Laurence-
dc.contributor.authorEzaz, M Tariq-
dc.contributor.authorBautista, Jose M-
dc.contributor.authorTocher, Douglas R-
dc.contributor.authorKrey, Grigorios-
dc.description.abstractThe cloning and characterization of cDNAs and genes encoding three peroxisome proliferator-activated receptor (PPAR) isotypes from two species of marine fish, the plaice (Pleuronectes platessa) and the gilthead sea bream (Sparus aurata), are reported for the first time. Although differences in the genomic organization of the fish PPAR genes compared with their mammalian counterparts are evident, sequence alignments and phylogenetic comparisons show the fish genes to be homologs of mammalian PPARα, PPARβ/δ, and PPARγ. Like their mammalian homologs, fish PPARs bind to a variety of natural PPAR response elements (PPREs) present in the promoters of mammalian or piscine genes. In contrast, the mRNA expression pattern of PPARs in the two fish species differs from that observed in other vertebrates. Thus, PPARγ is expressed more widely in fish tissues than in mammals, whereas PPARα and β are expressed similarly in profile to mammals. Furthermore, nutritional status strongly influences the expression of all three PPAR isotypes in liver, whereas it has no effect on PPAR expression in intestinal and adipose tissues. Fish PPARα and β exhibit an activation profile similar to that of the mammalian PPAR in response to a variety of activators/ligands, whereas PPARγ is not activated by mammalian PPARγ-specific ligands. Amino acid residues shown to be critical for ligand binding in mammalian PPARs are not conserved in fish PPARγ and therefore, together with the distinct tissue expression profile of this receptor, suggest potential differences in the function of PPARγ in fish compareden_UK
dc.publisherThe Endocrine Society-
dc.relationLeaver M, Boukouvala E, Antonopoulou E, Diez A, Favre-Krey L, Ezaz MT, Bautista JM, Tocher DR & Krey G (2005) Three peroxisome proliferator-activated receptor isotypes from each of two species of marine fish, Endocrinology, 146 (7), pp. 3150-3162.-
dc.rightsPublisher policy allows this work to be made available in this repository.-
dc.titleThree peroxisome proliferator-activated receptor isotypes from each of two species of marine fishen_UK
dc.typeJournal Articleen_UK
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationNational Agricultural Research Foundation-
dc.contributor.affiliationNational Agricultural Research Foundation-
dc.contributor.affiliationUniversidad Complutense de Madrid-
dc.contributor.affiliationNational Agricultural Research Foundation-
dc.contributor.affiliationUniversity of Stirling-
dc.contributor.affiliationUniversidad Complutense de Madrid-
dc.contributor.affiliationNational Agricultural Research Foundation-
Appears in Collections:Aquaculture Journal Articles

Files in This Item:
File Description SizeFormat 
tocher_endocrinology146_2005.pdf956.24 kBAdobe PDFView/Open

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.