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dc.contributor.authorHall, Jeremyen_UK
dc.contributor.authorWhalley, Heather Cen_UK
dc.contributor.authorMcKirdy, James Wen_UK
dc.contributor.authorSprengelmeyer, Reineren_UK
dc.contributor.authorSantos, Isabel Men_UK
dc.contributor.authorDonaldson, Daviden_UK
dc.contributor.authorMcGonigle, Daviden_UK
dc.contributor.authorYoung, Andrew Wen_UK
dc.contributor.authorMcIntosh, Andrew Men_UK
dc.contributor.authorJohnstone, Eve Cen_UK
dc.contributor.authorLawrie, Stephen Men_UK
dc.description.abstractBackground: A wide range of neuropsychiatric conditions, including schizophrenia and autistic spectrum disorder (ASD), are associated with impairments in social function. Previous studies have shown that individuals with schizophrenia and ASD have deficits in making a wide range of social judgements from faces, including decisions related to threat (such as judgements of approachability) and decisions not related to physical threat (such as judgements of intelligence). We have investigated healthy control participants to see whether there is a common neural system activated during such social decisions, on the basis that deficits in this system may contribute to the impairments seen in these disorders. Method: We investigated the neural basis of social decision making during judgements of approachability and intelligence from faces in 24 healthy participants using functional magnetic resonance imaging (fMRI). We used conjunction analysis to identify common brain regions activated during both tasks. Results: Activation of the amygdala, medial prefrontal cortex, inferior prefrontal cortex and cerebellum was seen during performance of both social tasks, compared to simple gender judgements from the same stimuli. Task-specific activations were present in the dorsolateral prefrontal cortex in the intelligence task and in the inferior and middle temporal cortex in the approachability task. Conclusions: The present study identified a common network of brain regions activated during the performance of two different forms of social judgement from faces. Dysfunction of this network is likely to contribute to the broad-ranging deficits in social function seen in psychiatric disorders such as schizophrenia and ASD.en_UK
dc.publisherCambridge University Pressen_UK
dc.relationHall J, Whalley HC, McKirdy JW, Sprengelmeyer R, Santos IM, Donaldson D, McGonigle D, Young AW, McIntosh AM, Johnstone EC & Lawrie SM (2010) A common neural system mediating two different forms of social judgement. Psychological Medicine, 40 (7), pp. 1183-1192.
dc.rightsPublisher policy allows this work to be made available in this repository. Published in Psychological Medicine by Cambridge University Press (CUP), copyright 2010. Psychological Medicine, Volume 40, Issue 07, July 2010, pp 1183-1192. DOI:
dc.subjectprefrontal cortexen_UK
dc.titleA common neural system mediating two different forms of social judgementen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitlePsychological Medicineen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of St Andrewsen_UK
dc.contributor.affiliationUniversity of Aveiroen_UK
dc.contributor.affiliationCardiff Universityen_UK
dc.contributor.affiliationUniversity of Yorken_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorHall, Jeremy|en_UK
local.rioxx.authorWhalley, Heather C|en_UK
local.rioxx.authorMcKirdy, James W|en_UK
local.rioxx.authorSprengelmeyer, Reiner|en_UK
local.rioxx.authorSantos, Isabel M|en_UK
local.rioxx.authorDonaldson, David|0000-0002-8036-3455en_UK
local.rioxx.authorMcGonigle, David|en_UK
local.rioxx.authorYoung, Andrew W|en_UK
local.rioxx.authorMcIntosh, Andrew M|en_UK
local.rioxx.authorJohnstone, Eve C|en_UK
local.rioxx.authorLawrie, Stephen M|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Psychology Journal Articles

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