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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Bacillus subtilis AB1 controls Aeromonas infection in rainbow trout (Oncorhynchus mykiss, Walbaum)
Author(s): Newaj-Fyzul, Aweeda
Adesiyun, Abiodun A
Mutani, A
Ramsubhag, A
Brunt, Jason
Austin, Brian
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Keywords: Aeromonas
Bacillus subtilis AB1
Fish disease
Innate immunity
Specific immunity
Issue Date: Nov-2007
Date Deposited: 8-Aug-2012
Citation: Newaj-Fyzul A, Adesiyun AA, Mutani A, Ramsubhag A, Brunt J & Austin B (2007) Bacillus subtilis AB1 controls Aeromonas infection in rainbow trout (Oncorhynchus mykiss, Walbaum). Journal of Applied Microbiology, 103 (5), pp. 1699-1706.
Abstract: Aim: To develop a probiotic with effectiveness against Aeromonas sp., which was pathogenic to rainbow trout. Methods and Results: When Bacillus subtilis AB1, which was obtained from fish intestine, was administered for 14 days to rainbow trout in feed at a concentration of 107 cells per gram either as viable, formalized or sonicated cells or as cell-free supernatant, the fish survived challenge with the pathogen. AB1 stimulated immune parameters, specifically stimulating respiratory burst, serum and gut lysozyme, peroxidase, phagocytic killing, total and a1-antiprotease and lymphocyte populations. Conclusions: Bacillus subtilis AB1 was effective as a probiotic at controlling infections by a fish-pathogenic Aeromonas sp. in rainbow trout. Significance and Impact of the Study: Disease control in fish is possible by means of the oral application of live and inactivated cells and their subcellular components with the mode of action reflecting stimulation of the innate immune response.
DOI Link: 10.1111/j.1365-2672.2007.03402.x
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