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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/38448
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dc.contributor.authorPF Bai, Janeen_UK
dc.contributor.authorBeigmohammadi, Fatemehen_UK
dc.contributor.authorCraig, Morganen_UK
dc.contributor.authorDalton, Mackenzieen_UK
dc.contributor.authorDesikan, Rajaten_UK
dc.contributor.authorEaslick, Terryen_UK
dc.contributor.authorGazeau, Soniaen_UK
dc.contributor.authorHeffernan, Janeen_UK
dc.contributor.authorKirpichnikova, Annaen_UK
dc.contributor.authorPadmanabhan, Praneshen_UK
dc.contributor.authorSachs, Jeffrey Ren_UK
dc.contributor.authorSher, Annaen_UK
dc.contributor.authorSkibinski, Daviden_UK
dc.contributor.authorSmith, Amber Men_UK
dc.date.accessioned2026-11-10T16:32:44Z-
dc.date.available2026-11-10T16:32:44Z-
dc.date.issued2026-10-24en_UK
dc.identifier.other128780en_UK
dc.identifier.urihttp://hdl.handle.net/1893/38448-
dc.description.abstractThis perspective paper illustrates how model-informed vaccine development (MIVD) impacts vaccine discovery and development decisions, saving time and resources. It discusses the benefits of mechanistic and other mathematical models within MIVD. We outline key applications, opportunities, challenges, and future steps for MIVD as a call for the continued integration of mathematical modelling during vaccine development.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationPF Bai J, Beigmohammadi F, Craig M, Dalton M, Desikan R, Easlick T, Gazeau S, Heffernan J, Kirpichnikova A, Padmanabhan P, Sachs JR, Sher A, Skibinski D & Smith AM (2026) The case for model-informed vaccine development. <i>Vaccine</i>, 92, Art. No.: 128780. https://doi.org/10.1016/j.vaccine.2026.128780en_UK
dc.rightsPF Bai, J., Beigmohammadi, F., Craig, M., Dalton, M., Desikan, R., Easlick, T., Gazeau, S., Heffernan, J., Kirpichnikova, A., Padmanabhan, P., Sachs, J. R., Sher, A., Skibinski, D., & Smith, A. M. (2026). The case for model-informed vaccine development. Vaccine, 92, 128780. DOI: https://doi.org/10.1016/j.vaccine.2026.128780 © 2026, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.subjectModel-informed vaccine developmenten_UK
dc.subjectMIVDen_UK
dc.subjectQuantitative systems pharmacology/toxicologyen_UK
dc.subjectQSP/Ten_UK
dc.subjectMathematical modelsen_UK
dc.titleThe case for model-informed vaccine developmenten_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2027-09-22en_UK
dc.identifier.doi10.1016/j.vaccine.2026.128780en_UK
dc.identifier.pmid42767025en_UK
dc.citation.jtitleVaccineen_UK
dc.citation.issn0264-410Xen_UK
dc.citation.volume92en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailsam.dixon@stir.ac.uken_UK
dc.citation.date21/09/2026en_UK
dc.contributor.affiliationU. S. Food and Drug Administrationen_UK
dc.contributor.affiliationUniversity of Montrealen_UK
dc.contributor.affiliationUniversity of Montrealen_UK
dc.contributor.affiliationClarkson Universityen_UK
dc.contributor.affiliationGlaxoSmithKlineen_UK
dc.contributor.affiliationUniversity of Montrealen_UK
dc.contributor.affiliationUniversity of Montrealen_UK
dc.contributor.affiliationYork University (Canada)en_UK
dc.contributor.affiliationMathematicsen_UK
dc.contributor.affiliationUniversity of Queenslanden_UK
dc.contributor.affiliationMerck (NJ)en_UK
dc.contributor.affiliationGlaxoSmithKlineen_UK
dc.contributor.affiliationCurevo Vaccineen_UK
dc.contributor.affiliationUniversity of Tennesseeen_UK
dc.identifier.scopusid105050626953en_UK
dc.identifier.wtid2265850en_UK
dc.contributor.orcid0000-0001-5153-7375en_UK
dc.date.accepted2026-05-27en_UK
dcterms.dateAccepted2026-05-27en_UK
dc.date.filedepositdate2026-10-08en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.versionAMen_UK
local.rioxx.authorPF Bai, Jane|en_UK
local.rioxx.authorBeigmohammadi, Fatemeh|en_UK
local.rioxx.authorCraig, Morgan|en_UK
local.rioxx.authorDalton, Mackenzie|en_UK
local.rioxx.authorDesikan, Rajat|en_UK
local.rioxx.authorEaslick, Terry|en_UK
local.rioxx.authorGazeau, Sonia|en_UK
local.rioxx.authorHeffernan, Jane|en_UK
local.rioxx.authorKirpichnikova, Anna|0000-0001-5153-7375en_UK
local.rioxx.authorPadmanabhan, Pranesh|en_UK
local.rioxx.authorSachs, Jeffrey R|en_UK
local.rioxx.authorSher, Anna|en_UK
local.rioxx.authorSkibinski, David|en_UK
local.rioxx.authorSmith, Amber M|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2027-09-22en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2027-09-21en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc-nd/4.0/|2027-09-22|en_UK
local.rioxx.filenameMIVDPerspectiveR1_clean (1).docxen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0264-410Xen_UK
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