Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/36522
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dc.contributor.authorOstridge, Harrison Jen_UK
dc.contributor.authorFontsere, Claudiaen_UK
dc.contributor.authorLizano, Estheren_UK
dc.contributor.authorSoto, Daniela Cen_UK
dc.contributor.authorSchmidt, Joshua Men_UK
dc.contributor.authorSaxena, Vrishtien_UK
dc.contributor.authorAlvarez-Estape, Marinaen_UK
dc.contributor.authorBarratt, Christopher Den_UK
dc.contributor.authorGratton, Paoloen_UK
dc.contributor.authorBocksberger, Gaëlleen_UK
dc.contributor.authorLester, Jack Den_UK
dc.contributor.authorDieguez, Paulaen_UK
dc.contributor.authorAgbor, Anthonyen_UK
dc.contributor.authorJeffery, Kathrynen_UK
dc.contributor.authorOrbell, Christopheren_UK
dc.date.accessioned2024-11-26T01:02:05Z-
dc.date.available2024-11-26T01:02:05Z-
dc.identifier.urihttp://hdl.handle.net/1893/36522-
dc.description.abstractHow populations adapt to their environment is a fundamental question in biology. Yet we know surprisingly little about this process, especially for endangered species such as non-human great apes. Chimpanzees, our closest living relatives, are particularly interesting because they inhabit diverse habitats, from rainforest to woodland-savannah. Whether genetic adaptation facilitates such habitat diversity remains unknown, despite having wide implications for evolutionary biology and conservation. Using 828 new exomes from wild chimpanzees (388 post-filtering), we find evidence of fine-scale genetic adaptation to habitat, with signatures of positive selection in forest chimpanzees in the same genes underlying adaptation to malaria in humans. This work demonstrates the power of non-invasive samples to reveal genetic adaptations in endangered populations and highlights the importance of adaptive genetic diversity for chimpanzees.en_UK
dc.language.isoenen_UK
dc.publisherAmerican Association for the Advancement of Scienceen_UK
dc.relationOstridge HJ, Fontsere C, Lizano E, Soto DC, Schmidt JM, Saxena V, Alvarez-Estape M, Barratt CD, Gratton P, Bocksberger G, Lester JD, Dieguez P, Agbor A, Jeffery K & Orbell C (2024) Local genetic adaptation to habitat in wild chimpanzees. <i>Science</i>.en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.titleLocal genetic adaptation to habitat in wild chimpanzeesen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2026-10-27en_UK
dc.rights.embargoreason[adn7954_ArticleContent_v11.docx] Until this work is published there will be an embargo on the full text of this work.en_UK
dc.citation.jtitleScienceen_UK
dc.citation.issn1095-9203en_UK
dc.citation.issn0036-8075en_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderNatural Environment Research Councilen_UK
dc.author.emailkathryn.jeffery1@stir.ac.uken_UK
dc.description.notesAdditional co-authors: Samuel Angedakin, Alfred Kwabena Assumang, Emma Bailey, Donatienne Barubiyo, Mattia Bessone, Gregory Brazzola, Rebecca Chancellor, Heather Cohen, Charlotte Coupland, Emmanuel Danquah, Tobias Deschner, Laia Dotras, Jef Dupain, Villard Ebot Egbe, Anne-Céline Granjon, Josephine Head, Daniela Hedwig, Veerle Hermans, R. Adriana Hernandez-Aguilar, Sorrel Jones, Jessica Junker, Parag Kadam, Michael Kaiser, Ammie K. Kalan, Mbangi Kambere, Ivonne Kienast, Deo Kujirakwinja, Kevin E. Langergraber, Juan Lapuente, Bradley Larson, Anne Laudisoit, Kevin C. Lee, Manuel Llana, Giovanna Maretti, Rumen Martín, Amelia C. Meier, David Morgan, Emily Neil, Sonia Nicholl, Stuart Nixon, Emmanuelle Normand, Lucy Jayne Ormsby, Robinson Orume, Liliana Pacheco, Jodie Preece, Sebastien Regnaut, Martha M. Robbins, Aaron Rundus, Crickette Sanz, Lilah Sciaky, Volker Sommer, Fiona A. Stewart, Nikki Tagg, Luc Roscelin Tédonzong, Joost van Schijndel, Elleni Vendras, Erin G. Wessling, Jacob Willie, Roman M. Wittig, Yisa Ginath Yuh, Kyle Yurkiw, Linda Vigilant, Alex K. Piel, Christophe Boesch, Hjalmar S. Kühl, Megan Y. Dennis, Tomas Marques-Bonet, Mimi Arandjelovic and Aida M. Andrésen_UK
dc.contributor.affiliationUniversity College Londonen_UK
dc.contributor.affiliationUniversity of Copenhagenen_UK
dc.contributor.affiliationInstitute of Evolutionary Biology (UPF-CSIC)en_UK
dc.contributor.affiliationUniversity of California, Davisen_UK
dc.contributor.affiliationFlinders Universityen_UK
dc.contributor.affiliationUniversity College Londonen_UK
dc.contributor.affiliationInstitute of Evolutionary Biology (UPF-CSIC)en_UK
dc.contributor.affiliationGerman Centre for Integrative Biodiversity Research (iDiv)en_UK
dc.contributor.affiliationUniversity of Rome, Italyen_UK
dc.contributor.affiliationSenckenberg Biodiversity and Climate Research Centre (BIK-F)en_UK
dc.contributor.affiliationMax Planck Institute for Evolutionary Anthropologyen_UK
dc.contributor.affiliationSenckenberg Museumen_UK
dc.contributor.affiliationMax Planck Institute for Evolutionary Anthropologyen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.identifier.wtid2072292en_UK
dc.contributor.orcid0000-0002-2632-0008en_UK
dc.contributor.orcid0000-0001-9338-9411en_UK
dc.date.accepted2024-10-27en_UK
dcterms.dateAccepted2024-10-27en_UK
dc.date.filedepositdate2024-11-18en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorOstridge, Harrison J|en_UK
local.rioxx.authorFontsere, Claudia|en_UK
local.rioxx.authorLizano, Esther|en_UK
local.rioxx.authorSoto, Daniela C|en_UK
local.rioxx.authorSchmidt, Joshua M|en_UK
local.rioxx.authorSaxena, Vrishti|en_UK
local.rioxx.authorAlvarez-Estape, Marina|en_UK
local.rioxx.authorBarratt, Christopher D|en_UK
local.rioxx.authorGratton, Paolo|en_UK
local.rioxx.authorBocksberger, Gaëlle|en_UK
local.rioxx.authorLester, Jack D|en_UK
local.rioxx.authorDieguez, Paula|en_UK
local.rioxx.authorAgbor, Anthony|en_UK
local.rioxx.authorJeffery, Kathryn|0000-0002-2632-0008en_UK
local.rioxx.authorOrbell, Christopher|0000-0001-9338-9411en_UK
local.rioxx.projectProject ID unknown|Natural Environment Research Council|http://dx.doi.org/10.13039/501100000270en_UK
local.rioxx.freetoreaddate2026-10-27en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2026-10-27en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2026-10-27|en_UK
local.rioxx.filenameadn7954_ArticleContent_v11.docxen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1095-9203en_UK
Appears in Collections:Biological and Environmental Sciences Journal Articles

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