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http://hdl.handle.net/1893/36382| Appears in Collections: | Faculty of Health Sciences and Sport Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Dose-dependency of a combined EPA:DHA mixture on incorporation, washout, and protein synthesis in C2C12 myotubes |
| Author(s): | Banic, M. van Dijk, M. Dijk, F.J. Furber, M.J.W. Witard, O.C. Donker, N. Becker, M.J.A. Galloway, S.D. Rodriguez-Sanchez, N. |
| Contact Email: | s.d.r.galloway@stir.ac.uk |
| Keywords: | Dose fish oil mTORC1 signaling n-3 PUFA time-course |
| Issue Date: | 25-Sep-2024 |
| Date Deposited: | 21-Oct-2024 |
| Citation: | Banic M, van Dijk M, Dijk F, Furber M, Witard O, Donker N, Becker M, Galloway S & Rodriguez-Sanchez N (2024) Dose-dependency of a combined EPA:DHA mixture on incorporation, washout, and protein synthesis in C2C12 myotubes. <i>Prostaglandins, Leukotrienes and Essential Fatty Acids</i>. https://doi.org/10.1016/j.plefa.2024.102651 |
| Abstract: | We demonstrate divergent incorporation and washout patterns for EPA and DHA following high and low-dose EPA+DHA incubation in C2C12 myotubes, with higher concentrations favoring n-3 PUFA incorporation. Lower n-3 PUFA concentrations increased MPS without further upregulating the mTORC1 signaling pathway. Our study provides novel insights into the temporal incorporation and washout dynamics of EPA and DHA and, specifically, their combined effect on MPS, thereby advancing knowledge regarding dietary n-3 PUFA prescription to promote skeletal muscle health in humans. |
| DOI Link: | 10.1016/j.plefa.2024.102651 |
| Rights: | This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article. |
| Notes: | Output Status: Forthcoming/Available Online |
| Licence URL(s): | http://creativecommons.org/licenses/by/4.0/ |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Dose-dependency of a combined EPA-DHA mixture on incorporation pre-proof.pdf | Fulltext - Accepted Version | 705.89 kB | Adobe PDF | View/Open |
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