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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/36382
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dc.contributor.authorBanic, M.en_UK
dc.contributor.authorvan Dijk, M.en_UK
dc.contributor.authorDijk, F.J.en_UK
dc.contributor.authorFurber, M.J.W.en_UK
dc.contributor.authorWitard, O.C.en_UK
dc.contributor.authorDonker, N.en_UK
dc.contributor.authorBecker, M.J.A.en_UK
dc.contributor.authorGalloway, S.D.en_UK
dc.contributor.authorRodriguez-Sanchez, N.en_UK
dc.date.accessioned2024-10-23T00:00:33Z-
dc.date.available2024-10-23T00:00:33Z-
dc.date.issued2024-09-25en_UK
dc.identifier.urihttp://hdl.handle.net/1893/36382-
dc.description.abstractWe demonstrate divergent incorporation and washout patterns for EPA and DHA following high and low-dose EPA+DHA incubation in C2C12 myotubes, with higher concentrations favoring n-3 PUFA incorporation. Lower n-3 PUFA concentrations increased MPS without further upregulating the mTORC1 signaling pathway. Our study provides novel insights into the temporal incorporation and washout dynamics of EPA and DHA and, specifically, their combined effect on MPS, thereby advancing knowledge regarding dietary n-3 PUFA prescription to promote skeletal muscle health in humans.en_UK
dc.language.isoenen_UK
dc.publisherElsevier BVen_UK
dc.relationBanic M, van Dijk M, Dijk F, Furber M, Witard O, Donker N, Becker M, Galloway S & Rodriguez-Sanchez N (2024) Dose-dependency of a combined EPA:DHA mixture on incorporation, washout, and protein synthesis in C2C12 myotubes. <i>Prostaglandins, Leukotrienes and Essential Fatty Acids</i>. https://doi.org/10.1016/j.plefa.2024.102651en_UK
dc.rightsThis is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectDoseen_UK
dc.subjectfish oilen_UK
dc.subjectmTORC1 signalingen_UK
dc.subjectn-3 PUFAen_UK
dc.subjecttime-courseen_UK
dc.titleDose-dependency of a combined EPA:DHA mixture on incorporation, washout, and protein synthesis in C2C12 myotubesen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.plefa.2024.102651en_UK
dc.citation.jtitleProstaglandins, Leukotrienes and Essential Fatty Acidsen_UK
dc.citation.issn1532-2823en_UK
dc.citation.issn0952-3278en_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderNutricia Research Foundationen_UK
dc.author.emails.d.r.galloway@stir.ac.uken_UK
dc.citation.date25/09/2024en_UK
dc.description.notesOutput Status: Forthcoming/Available Onlineen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationDanone Research & Innovation UTRECHTen_UK
dc.contributor.affiliationDanone Research & Innovation UTRECHTen_UK
dc.contributor.affiliationDanone Research & Innovation UTRECHTen_UK
dc.contributor.affiliationDanone Research & Innovation UTRECHTen_UK
dc.contributor.affiliationDanone Research & Innovation UTRECHTen_UK
dc.contributor.affiliationDanone Research & Innovation UTRECHTen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationSporten_UK
dc.identifier.wtid2056170en_UK
dc.contributor.orcid0000-0003-1541-9421en_UK
dc.contributor.orcid0000-0002-1622-3044en_UK
dc.contributor.orcid0000-0003-3960-5704en_UK
dc.date.accepted2024-09-20en_UK
dcterms.dateAccepted2024-09-20en_UK
dc.date.filedepositdate2024-10-21en_UK
dc.relation.funderprojectImpact of omega (ω)-3 polyunsaturated fatty acids (n-3 PUFA) upon muscle health/functionen_UK
dc.relation.funderrefsee attached agreementen_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorBanic, M.|0000-0003-1541-9421en_UK
local.rioxx.authorvan Dijk, M.|en_UK
local.rioxx.authorDijk, F.J.|en_UK
local.rioxx.authorFurber, M.J.W.|en_UK
local.rioxx.authorWitard, O.C.|en_UK
local.rioxx.authorDonker, N.|en_UK
local.rioxx.authorBecker, M.J.A.|en_UK
local.rioxx.authorGalloway, S.D.|0000-0002-1622-3044en_UK
local.rioxx.authorRodriguez-Sanchez, N.|0000-0003-3960-5704en_UK
local.rioxx.projectsee attached agreement|Nutricia Research Foundation|http://dx.doi.org/10.13039/501100001720en_UK
local.rioxx.freetoreaddate2024-10-21en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2024-10-21|en_UK
local.rioxx.filenameDose-dependency of a combined EPA-DHA mixture on incorporation pre-proof.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1532-2823en_UK
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