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http://hdl.handle.net/1893/34585| Appears in Collections: | Biological and Environmental Sciences Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Broad toxicological effects of Per-/Poly- fluoroalkyl substances (PFAS) on the unicellular eukaryote, Tetrahymena pyriformis |
| Author(s): | Lim, Jenson |
| Contact Email: | jenson.lim@stir.ac.uk |
| Keywords: | Tetrahymena Perfluorooctanoic acid (PFOA) Perfluorooctanesulfonic acid (PFOS) phagocytosis cell division reactive oxygen species |
| Issue Date: | Oct-2022 |
| Date Deposited: | 12-Oct-2022 |
| Citation: | Lim J (2022) Broad toxicological effects of Per-/Poly- fluoroalkyl substances (PFAS) on the unicellular eukaryote, Tetrahymena pyriformis. Environmental Toxicology and Pharmacology, 95, Art. No.: 103954. https://doi.org/10.1016/j.etap.2022.103954 |
| Abstract: | Per-/Poly- fluoroalkyl substances represent emerging persistent organic pollutants. Their toxic effects can be broad, yet little attention has been given to organisms at the microscale. To address this knowledge shortfall, the unicellular eukaryote Tetrahymena pyriformis was exposed to increasing concentrations (0 - 5000 μM) of PFOA/PFOS and monitored for cellular motility, division and function (i.e., phagocytosis), reactive oxygen species generation and total protein levels. Both PFOA/PFOS exposure had negative impacts on T. pyriformis, including reduced motility, delayed cell division and oxidative imbalance, with each chemical having distinct toxicological profiles. T. pyriformis represents a promising candidate for assessing the biological effects these emerging anthropogenically-derived contaminants in a freshwater setting. |
| DOI Link: | 10.1016/j.etap.2022.103954 |
| Rights: | This is an open access article distributed under the terms of the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article. |
| Licence URL(s): | http://creativecommons.org/licenses/by/4.0/ |
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|---|---|---|---|---|
| 1-s2.0-S1382668922001478-main.pdf | Fulltext - Published Version | 1.49 MB | Adobe PDF | View/Open |
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